Lomefloxacin Hydrochloride Capsules

This product is a quinolone antibacterial drug. It has high antibacterial activity against Enterobacteriaceae such as Escherichia coli, Shigella, Klebsiella, Proteus, Enterobacter, etc.; Haemophilus influenzae and Neisseria gonorrhoeae are also highly sensitive to this product; it also has certain antibacterial effects on Pseudomonas such as Acinetobacter, Pseudomonas aeruginosa, Staphylococcus and Pneumococcus, hemolytic Streptococcus, etc. This product acts on the A subunit of DNA helicase in bacterial cells, inhibiting the synthesis and replication of DNA and exerting a bactericidal effect.

Lomefloxacin hydrochloride

This product is in the form of capsules.

This product is suitable for the following infections caused by sensitive bacteria: 1. Respiratory tract infection. 2. Urinary and reproductive system infection. 3. Gastrointestinal bacterial infection. 4. Infections of the abdominal cavity, bile duct, typhoid fever, etc. 5. Bone and joint infection. 6. Skin and soft tissue infection. 7. Systemic infection such as sepsis. 8. Other infections, such as sinusitis, otitis media, blepharitis, etc.

1 Bacterial bronchial infection: Oral administration of 0.4g once a day, or 0.3g once a day, twice a day, for a course of 7 to 14 days. 2 Acute simple urinary tract infection: Oral administration of 0.4g once a day, for a course of 7 to 10 days; complicated urinary tract infection: Oral administration of 0.4g once a day, for a course of 14 days. 3 Simple gonorrhea: Oral administration of 0.3g once a day, twice a day. 4 Prevention of surgical infection: Oral administration of 0.4g once a day, 2 to 6 hours before surgery.

1. Gastrointestinal reactions are relatively common and may manifest as abdominal discomfort or pain, diarrhea, nausea or vomiting. 2. Central nervous system reactions: dizziness, headache, drowsiness or insomnia may occur. 3. Allergic reactions: rash, skin itching, and occasionally exudative erythema multiforme and angioneurotic edema. Photosensitivity reactions are more common than other commonly used quinolones. 4. A small number of patients may experience increased serum aminotransferase and BUN values and decreased peripheral blood white blood cells, which are mostly mild and transient. 5. Occasionally, the following may occur: (1) Epileptic seizures, mental abnormalities, irritability, confusion, hallucinations, and tremors. (2) Interstitial nephritis manifestations such as hematuria, fever, and rash. (3) Crystalluria, which is more common when used in high doses. (4) Joint pain.

1. It is contraindicated for those who are allergic to this product or other quinolone drugs. 2. It is contraindicated for pregnant women, infants and patients under 18 years old.

Precautions for children: This product can cause permanent damage to the cartilage of the weight-bearing joints of dogs, resulting in lameness. It can also cause arthritis in several other underage animals, so it is contraindicated for infants and children under 18 years old. Precautions for pregnancy and lactation: This product can pass through the blood-placental barrier and is contraindicated for pregnant women. This product can also be secreted into breast milk, and its concentration is close to the blood drug concentration. Lactating women should stop breastfeeding when using this product. Precautions for the elderly: Elderly patients have decreased renal function, and the dosage should be reduced as appropriate.

1. This product has little effect on the liver metabolism and body clearance of theophylline drugs and caffeine. 2. Aluminum sulfate and antacids can slow down the absorption rate of this product by 25%, and reduce the area under the curve (AUC) by about 30%. If saccharofaluminum sulfate and antacids are taken 4 hours before or 6 hours after taking this product, the effect will be minimal. 3. Combination with fenbufen can cause central nervous system excitement and epileptic seizures. 4. Probenecid can delay the excretion of this product, increase the average area under the curve (AUC) by 63%, extend the average peak time (tmax) by 50%, and increase the average peak concentration (Cmax) by 4%; therefore, when used together, toxicity may occur due to the increased blood concentration of this product. 5. It can enhance the effects of oral anticoagulants such as warfarin, and the prothrombin time and other items should be monitored. 6. Urine alkalinizers can reduce the solubility of this product in urine, leading to crystalluria and nephrotoxicity. 7. Didanosine (DDI) preparations contain aluminum and magnesium that can chelate with quinolones and should not be used together. 8. When used together with cyclosporine, the blood concentration of cyclosporine can be increased. The blood concentration of cyclosporine must be monitored and the dosage adjusted. 9. Nutritional supplements and vitamins containing metal ions should not be taken within 2 hours before or after taking this product.

Keep away from light and store in sealed container.

0.1g (based on C17H19F2N3O3)

36 months

Jinzhou Jiuyang Pharmaceutical Co., Ltd.

• Founded in:

  1998-12-25

• Address:

  No. 6, Section 3, Jingang Street, Jinzhou Economic and Technological Development Zone, Liaoning Province

• Tax NO.:

  912107007016206591

• Registered Funds:

  10 million yuan

• Email:

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