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Nepafenac 98%

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CAS No.:

78281-72-8

Grade:

Pharmaceutical Grade

Content:

98%

Port:

QINGDAO

Packaging:

0.2kg/0.2kg Bag

Price valid (until):

2020-05-25

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Jinan Chenghuishuangda Chemical Co.,Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

4-(4-Pyridinyl)thiazole-2-thiol,3,20-Bis(ethylenedioxy)-19-norpregna-5(10)9(11)dien-17-ol,3,3-Dimethylbutyraldehyde,Articaine hydrochloride,7-AMINOHEPTANOIC ACID HYDROCHLORIDE,3-Acetyl-2,5-dichlorothiophene

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Product Description
Seller Information
Inquiry History

Description

Ophthalmic medication (cataract) Nepafenac (Nepafenac) is a new type of ophthalmic non-steroidal antipyretic and analgesic anti-inflammatory drugs (NSAIDs), used to treat ocular pain and inflammation caused by cataract surgery, compared with traditional NSAIDs In contrast, the chemical structure of nepafenac is beneficial for the drug to penetrate the cornea quickly and be distributed at its target site, thus helping to reduce the accumulation of drugs on the corneal surface and the occurrence of complications on the surface of the eyeball. It has the advantages of strong targeting effect and low toxic and side effects. On August 19, 2005, the US Food and Drug Administration (FDA) approved nepafenac ophthalmic suspension for the treatment of cataract surgery-related pain and inflammation. It was the first approved ophthalmic NSAID prodrug formulation to be marketed. When nepafenac is administered through the eye, it can quickly pass through the cornea and be converted to amfenac (an NSAID) under the action of ocular tissue hydrolase; Cyclooxygenase), which blocks the synthesis of prostaglandins to exert its anti-inflammatory and analgesic effects. As people know, prostaglandins are one of the mediators that cause inflammation in the eye, which can lead to the collapse of the blood-aqueous barrier, vasodilation, increased vascular permeability, and leukocyte chemotaxis. In addition, prostaglandins can also pass non-choline The mechanism can contract the iris sphincter, triggering myopic reaction during and after eye surgery. After administration of NSAIDs through the eye, it can inhibit the synthesis of prostaglandins in the iris, ciliary body and conjunctiva, so it can prevent the occurrence of eye inflammation and reduce related pain.

Basic Info

Product Name:

Nepafenac

Other Name:

Benzeneacetamide,2-amino-3-benzoyl-;2-Amino-3-benzoylbenzeneacetamide;AL 6515;Nepafenac;AHR 9434;Nevanac;Ilevro;2-(2-Amino-3-benzoylphenyl)acetamide

CAS No.:

78281-72-8

Molecular Formula:

C15H14N2O2

InChIKeys:

InChIKey=QEFAQIPZVLVERP-UHFFFAOYSA-N

Molecular Weight:

254.28400

Exact Mass:

254.28

UNII:

0J9L7J6V8C

DSSTox ID:

DTXSID0048638

NCI Thesaurus Code:

C66228

ATC Code:

S01BC10|S - Sensory organs

HScode:

2924299090

Categories:

Inhibitors

Characteristics

PSA:

86.18000

XLogP3:

1.9

Appearance:

Solid

Density:

1.249 g/cm3

Melting Point:

178-180 °C @ Solvent: Isopropanol

Boiling Point:

562.5ºC at 760 mmHg

Flash Point:

294ºC

Refractive Index:

1.641

Storage Conditions:

Refrigerator

See More Nepafenac Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H400 Very toxic to aquatic life
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nepafenac Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Location:
No.2350 Kaituo Road,Jinan,Shandong China

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	NEPAFENAC	1 KG	May 13, 2026

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