Lapatinib Chemical Grade
231277-92-2
Chemical Grade
99%
SHANGHAI
25kg/negotiable
2020-05-20
Research and Development,Promotion and Transfer of,5-Amino-2,4,6-triiodoisophthaloyl dichloride,5-Amino-2,4,6-triiodoisophthalic acid,3-Aminophthalimide,p-Hydroxyphenylacetic acid,1-(3-Nitrophenyl)propanone
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceLapatinib (GW572016) is a potent EGFR and ErbB2 inhibitor with IC50s of 10.2 and 9.8 nM, respectively.
Solid
Lapatinib is an organofluorine compound, an organochlorine compound, a member of quinazolines and a member of furans. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It derives from a monofluorobenzene.|Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug Capecitabine. Lapatinib is human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1) tyrosine kinases inhibitor. It binds to the intracellular phosphorylation domain to prevent receptor autophosphorylation upon ligand binding.|Lapatinib is a Kinase Inhibitor. The mechanism of action of lapatinib is as a Protein Kinase Inhibitor.|Lapatinib is a small molecule inhibitor of several tyrosine kinase receptors involved in tumor cell growth that is used in the therapy of advanced breast cancer and other solid tumors. Lapatinib therapy is associated with transient elevations in serum aminotransferase levels and rare instances of clinically apparent acute liver injury.|Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.|A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.Basic Info-
Product Name:
Lapatinib
Other Name:4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine;GW 572016;Lapatinib;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline;GSK 572016;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;GW 572016X;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;Tyverb;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine;GD 2016;Tycerb
CAS No.:231277-92-2
Molecular Formula:C29H26ClFN4O4S
InChIKeys:InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N
Molecular Weight:581.0575432
Exact Mass:581.06
EC Number:1806241-263-5
UNII:0VUA21238F
NSC Number:745750
DSSTox ID:DTXSID7046675
NCI Thesaurus Code:C26653
ATC Code:L01XE07|L - Antineoplastic and immunomodulating agents
HScode:2934999090
Characteristics-
PSA:
115
XLogP3:5.1
Appearance:Solid
Density:1.4±0.1 g/cm3
Boiling Point:750.7°C at 760 mmHg
Flash Point:407.8±32.9 °C
Refractive Index:1.645
Water Solubility:2.23e-02 g/L
Storage Conditions:Store at 25 deg C (77 deg F); excursions permitted to 15 deg to 30 deg C (59 deg to 86 deg F).
Vapor Pressure:1.63X10-17 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 4.93X10-22 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 3.80 (amine); pKa2 = 7.20 (amine)
Experimental Properties:Hydroxyl radical reaction rate constant = 3.04X10-10 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Research and Development,Promotion and Transfer of,5-Amino-2,4,6-triiodoisophthaloyl dichloride,5-Amino-2,4,6-triiodoisophthalic acid,3-Aminophthalimide,p-Hydroxyphenylacetic acid,1-(3-Nitrophenyl)propanone
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Location:
Room1803, Huatai Building, No. 1 Zhongxing Avenue, Taixing City, Jiangsu Province
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Payment Terms:
D/P,L/C,D/A
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2017
Taixing Joxin Bio-tec Co.,Ltd. Located in the Yangtze River Delta, Yangtze River, beautiful and rich in central Jiangsu.
The company is a high-tech development, production, management, import and export, sales as one of the high-tech R & D enterprises. Main chemical, biotechnology research and development, the Company in Jiangsu, Shandong, Anhui, Jiangxi nitrification, halogenation, esterification, reduction and other reaction production lines. The company in the "quality-oriented, reputation first" and the purpose, with "realistic and innovative, unity and dedication" and the entrepreneurial spirit, has developed a developer, cardiovascular and other pharmaceutical intermediates, dyes intermediates, pesticide kill Insecticide intermediates, rubber accelerators, film brightener, copperplate additives and a variety of organic synthesis intermediates and fine chemicals. Has a stable domestic and foreign markets, while constantly developing new products. At present the company's products are mainly exported to Europe and the United States, Japan, Korea and India and other countries and regions.I will, as always, the excellence, and constantly strengthen the scientific management of enterprises, improve the technological content of products, unswervingly follow the quality of survival, efficiency and efficiency, customer-centric "business philosophy and improve the enthusiasm After-sales service. We sincerely hope that through the joint efforts of both of us, with a view to mutual benefit in business and friendship to achieve a win-win situation in order to cooperate through our sincere cooperation for a better future.
You are welcome to cooperate with my company, negotiate, and sincerely hope to have the opportunity to provide you with services
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