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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Lapatinib for Sale > Lapatinib Pharmaceutical Intermediate Lapatinib
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Lapatinib Pharmaceutical Intermediate Lapatinib

Unit Price: Get Latest Price
CAS No.:

231277-92-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

QINGDAO

Brand:

HebeiShunXing

Packaging:

25KG/Bag

Price valid (until):

2025-08-08

Company Type:
Trader
Location:
China
Qualification:
Main Products:

HPMC,Lithium Carbonate,Cellulose Acetate Tow,EVA resin,Terpene Resin,PP fiber

  • Product Description

  • Seller Information

  • Description


      Product Detail  


    Product Name: Lapatinib
    CAS: 231277-92-2
    MF: C29H26ClFN4O4S
    MW: 581.0575432
    EINECS: 621-260-7

    Melting point: 96-97°C
    Boiling point: 750.7±60.0 °C
    Density: 1.381±0.06 g/cm3
    Storage temp.: Store at RT
    Appearance: Off-White Powder

    Description:

    Lapatinib, a new member of the 4-anilinoquinazoline class of RTK inhibitors (RTKIs), was launched as an oral treatment for breast cancer. Lapatinib has dual affinity for EGFR and HER2 tyrosine kinases. It is indicated in combination with cape citabine for treating patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastu zumab.

    Uses:

    Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively.



    Packing and transportation  


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    The product is packed in polyethylene bag enclosed in composite fiberboard drum or paper bag.
    The net weight is 25 kg/drum or 25 kg/bag  .
    The product should be kept in the original bag and stored in the dry and clean place far away from the source of heat and not put together with other chemicals.


      Corporate advantage


    Hebei Shunxing Import and Export Co., Ltd. is a large chemical trading company in North China. The company not only excels in service, but also strictly controls product quality.

    Over the years, quality testing technology has been continuously improved, and an industry level quality inspection and supervision system has been established. Equipped with advanced domestic quality testing instruments, product quality has steadily improved, winning the support and trust of more customers!

    The company has established a sound and excellent domestic and international marketing system, providing customers with various high-quality and cost-effective chemical raw materials.

    At the same time, it fully utilizes its extensive sales channels and business experience, and also leverages the advanced professional technology of foreign partners such as Japan to provide customers with consulting services such as technology introduction. As a professional trading company, we have maintained good cooperative relationships with major manufacturers across the country for a long time, and have signed long-term sales agency contracts with multiple domestic and foreign customers.

    We have a stable and good customer base in both domestic and foreign markets, and have also established reliable partnerships with well-known enterprises in countries and regions such as Japan and Southeast Asia.


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    P roduction:our associate factory possesses 20000T/a of capacity for Phospha tes & 3000T/a of capacity for polymers. And it possess production facility conforms to G M P standard, which could assure you high quality APIs and intermediates.

    R & D: our associate factory own synthetic and biochemical labs, sophisticated multifunctional pilot workshop which is able to customize chemical products from the level in gram to that in kilogram and excel at process scale-up from lab to workshop.

    Export:1. Water treatment chemicals, mainly includes series of organic , biocide and polymer.
    2. Fine chemicals, mainly includes flame retardant, pharmaceutical raw materials & intermediates. Our products are exported to many countries and areas such as Europe, North America, South America, Southeast Asia, etc.


    Basic Info
    Product Name:

    Lapatinib

    Other Name:

    4-Quinazolinamine,N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine;GW 572016;Lapatinib;4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline;GSK 572016;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;GW 572016X;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methanesulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine;Tyverb;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;N-[4-(3-Fluorobenzyloxy)-3-chlorophenyl]-6-[5-[[2-(methylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine;GD 2016;Tycerb

    CAS No.:

    231277-92-2

    Molecular Formula:

    C29H26ClFN4O4S

    InChIKeys:

    InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

    Molecular Weight:

    581.0575432

    Exact Mass:

    581.06

    EC Number:

    1806241-263-5

    UNII:

    0VUA21238F

    NSC Number:

    745750

    DSSTox ID:

    DTXSID7046675

    NCI Thesaurus Code:

    C26653

    ATC Code:

    L01XE07|L - Antineoplastic and immunomodulating agents

    HScode:

    2934999090

    Characteristics
    PSA:

    115

    XLogP3:

    5.1

    Appearance:

    Solid

    Density:

    1.4±0.1 g/cm3

    Boiling Point:

    750.7°C at 760 mmHg

    Flash Point:

    407.8±32.9 °C

    Refractive Index:

    1.645

    Water Solubility:

    2.23e-02 g/L

    Storage Conditions:

    Store at 25 deg C (77 deg F); excursions permitted to 15 deg to 30 deg C (59 deg to 86 deg F).

    Vapor Pressure:

    1.63X10-17 mm Hg at 25 deg C (est)

    Henrys Law Constant:

    Henry's Law constant = 4.93X10-22 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa1 = 3.80 (amine); pKa2 = 7.20 (amine)

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 3.04X10-10 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    HPMC,Lithium Carbonate,Cellulose Acetate Tow,EVA resin,Terpene Resin,PP fiber

    Location:

    Building 4, Feicui Building, No. 366 Xinshi North Road, Qiaoxi District, Shijiazhuang City, Hebei Province

    Payment Terms:

    TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    51-100

    Year of Establishment:

    2024

    Hebei Shunxing Import and Export Co., Ltd. distributes and wholesales best-selling chemical products in the consumer market, enjoying a high position among consumers. The company has established long-term and stable cooperative relationships with multiple retailers and agents. The company was founded in 2012 and has a sales history of over 10 years. There are around 160 employees. Hebei Shunxing Import and Export Co., Ltd. operates a complete range of chemical products at reasonable prices. Our company has strong strength, values credit, abides by contracts, and guarantees product quality. With the characteristics of diversified business and the principle of small profits and quick sales, we have gained the trust of more and more customers. In today's increasingly transparent product prices, our company has won the trust of our customers with its thoughtful service and excellent product quality, and has established a mutually beneficial cooperative relationship with them. The company will continue to make friends from all walks of life in an honest and mutually beneficial manner, warmly welcoming friends from all walks of life。

    The company's main products are HPMC, PM, MDEA, LAS60%, Tween (R) 80, EDTA,white oil and so on.Most of them belong to general organic chemicals

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