The leader in biochemical tests-lithium heparin

Heparin is commonly used in clinical blood tests with sodium and lithium salts, and has unique application value. Heparin has low chelating power, has little effect on the movement of water molecules, has little interference with blood components, does not affect the volume of red blood cells, and does not cause hemolysis, so In many tests that use whole blood or plasma as a specimen, heparin is recommended as an anticoagulant.

Lithium heparin and sodium heparin both have anticoagulant effects in clinical practice, mainly used for thromboembolic diseases, myocardial infarction, cardiovascular surgery, cardiac catheterization, extracorporeal circulation, hemodialysis, etc. Because the combined ions are different, so Its dissociation degree is different, and the effect of lithium heparin is better than that of heparin sodium. 

In the detection of pH, blood gas, electrolytes and calcium ions, heparin is the only anticoagulant that can be used, and lithium heparin has the least possibility of interference when detecting non-lithium ions, so it is recommended to use heparin lithium as an anticoagulant At present, in blood tests, lithium heparin is gradually replacing heparin sodium.

For biochemical examination of patients after hemodialysis

The blood sample of a patient after hemodialysis is a special sample faced by many hospital laboratory departments, and many inspectors often feel helpless when facing such samples. This is because dialysis patients use heparin-containing anticoagulant drugs such as low molecular weight heparin calcium during hemodialysis. At this time, because the blood contains a certain amount of heparin anticoagulant drugs, the blood is placed in a common tube or separation gel after the blood is drawn /The coagulant tube is extremely difficult to coagulate, and it is difficult to separate the serum.

It has been reported that lithium heparin anticoagulated plasma and serum are used to test blood K. The analysis of the test results is biased. It may be that the blood sample rotates too high during the centrifugation process, and the red blood cells in the blood clot covered by the fibrin mesh are squeezed and destroyed. The release of K ions into the serum. In addition, a small amount of red blood cells will inevitably be destroyed during the transportation and coagulation of the blood sample, resulting in a slightly high blood K.

It is also reported that there are significant differences between the results of CK-MB, LDH, GLU, etc., between the use of lithium heparin anticoagulated plasma and serum, which may be caused by the hemolysis of the specimen or the decomposition of blood sugar for too long. On the contrary, heparin anticoagulant has the advantages of not affecting cell volume and not easily causing hemolysis. It does not need to be placed in a water bath and can be centrifuged directly. The blood K, GLU, LDH, etc. measured with lithium heparin anticoagulated plasma are more accurate to the true concentration in the patient's body. Therefore, the establishment of a plasma biochemical test reference value system as soon as possible will help clinicians make accurate judgments on the patient's condition.

For routine biochemical testing

Research results show that most routine biochemical test items can use lithium heparin anticoagulated plasma instead of serum, but plasma reference ranges should be established for Glu, K+, Na+, CI-, P3-, and serum reference ranges can be used for other items to interpret plasma test results; Lp( a), PA, HBDH, LDH, CK, CKMB, IgM and other items should not be measured with lithium heparin anticoagulated plasma samples. Plasma Lp(a) increases with the increase of heparin concentration.

Desheng has been in the R&D and production of blood collection tube additives for 15 years. It can be said to be an old-brand manufacturer of blood collection tube additives. Heparin sodium and lithium heparin are our main products. They are non-injectable grades and are mainly used for collection. The anticoagulant in vascular additives, that is, in vitro anticoagulant, is recommended by many companies for purchase. And we can also customize heparin products with a potency of 150IU-180IU according to customer needs.