Heparin is a kind of mucopolysaccharide with sulfate group extracted from intestinal mucosa. It is a kind of bioactive substance with strong negative charge. Heparin can activate antithrombin III and inactivate serine protease in blood, thus preventing the formation of thrombin and platelet aggregation. So we encountered the following problems in the use process, how to solve them?
What's the difference between heparin sodium and heparin lithium as blood collection vessels?
A: the binding ion is different: Although heparin lithium and heparin sodium are anticoagulant blood, they are also a binding form of heparin, but the effective ion binding is different, which also makes it look the same in appearance. Heparin lithium and heparin sodium are essentially different in texture, and their dissociation degree is also different. It can be said that heparin lithium is replaced from heparin sodium.
The doses added to the blood collection vessels are different: heparin lithium and heparin sodium are actually used in the vacuum blood collection vessels, while the dose range of heparin lithium in the industry standard is 9.4iu ~ 28iu / ml, and heparin sodium is 12iu ~ 30iu / ml blood. The heparin lithium and heparin sodium of one milliliter of blood collected in venous vacuum were 15iu-20iu.
What grade of heparin lithium is needed in blood collection?
A: heparin lithium in blood collection vessel needs biochemical heparin lithium.
Heparin lithium as a common blood routine tube additives, the recommended dosage is how much?
A: generally, the recommended dosage is 15-25iu / ml blood, and the recommended dosage is 20iu / ml. the specific usage can be carried out according to the actual situation.
Why does some heparin lithium tube appear tiny coagulation fragments after blood collection?
A: This is because the local anticoagulant concentration in the heparin lithium anticoagulant tube is too high, resulting in that part of the blood can not be fully mixed with heparin lithium after entering the blood collection vessel, resulting in some micro clots. This may be due to the failure to reverse the mixing tube in time after blood collection.
Can heparin lithium be used as additive for other tubes besides green headgear?
A: Yes. It can be used with sodium fluoride and separation gel. When heparin lithium and sodium fluoride are used together, it can be used for blood glucose tube, adding about 20 IU per milliliter of blood. When heparin lithium is used with separation gel, the dosage of heparin lithium is the same, and 0.8-1.2g separation gel can be added to each branch.
What are the storage conditions of heparin lithium?
A: This product can be sealed in a cool and dry place, away from light and damp. The water solution of this product can be sealed at 0-4 ℃ under sterile condition, and the longest storage period should not exceed 7 days. It is recommended that this product be ready to use in aqueous solution and not stored in solution for a long time. Heparin lithium should not be used when there are impurities, abnormal smell, color and shelf life.
