Mesalazine 99% white powder
3 Inquiries
89-57-6
USP/EP
99%
shanghai
25kg/carton
2021-06-30
Sucralose
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial Reference5-Aminosalicylic acid acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
5-aminosalicylic acid appears as odorless white to pinkish crystals or purplish-tan powder. Aqueous solutions acidic (pH approximately 4.1 at 0.8 mg/L water) . (NTP, 1992)|Solid
5-aminosalicylic acid appears as odorless white to pinkish crystals or purplish-tan powder. Aqueous solutions acidic (pH approximately 4.1 at 0.8 mg/L water) . (NTP, 1992)|Mesalamine is a monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug. It is an aromatic amine, an amino acid, a member of phenols, a monocarboxylic acid and a monohydroxybenzoic acid. It derives from a salicylic acid. It is a conjugate acid of a mesalaminate(1-).|An anti-inflammatory agent, structurally related to the salicylates and non-steroidal anti-inflammatory drugs like acetylsalicylic acid, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed) Although demonstrably effective in treating and maintaining remission for ulcerative colitis, mesalazine has historically faced a number of issues regarding its lack of stability as a pharmaceutical agent. Throughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation of mesalazine within microgranules. In the present day, contemporary research regarding novel methods to stabilize mesalazine continues and interest in the agent's capacity to decrease inflammatory activity and subsequently potentially reduce the risk of colorectal cancer in conditions like ulcerative colitis is maintained.|Mesalamine is an Aminosalicylate.|Mesalamine, also known as mesalazine and 5-aminosalicylate, is an orally available, antiinflammatory agent used for the treatment of ulcerative colitis to both induce and maintain remissions in disease. Mesalamine therapy has been associated with a low rate of serum enzyme elevations during therapy and with rare instances of clinically apparent acute liver injury.|Mesalamine is an agent derived from sulfasalazine, an antiinflammatory agent. Mesalamine may reduce inflammation through inhibition of cyclooxygenase and prostaglandin production. Following rectal or oral administration, only a small amount of mesalamine is absorbed; the remainder, acting topically, reduces bowel inflammation, diarrhea, rectal bleeding and stomach pain. (NCI04)|An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)Basic Info-
Product Name:
5-Aminosalicylic acid
Other Name:Benzoic acid,5-amino-2-hydroxy-;Salicylic acid,5-amino-;5-Amino-2-hydroxybenzoic acid;2-Hydroxy-5-aminobenzoic acid;3-Carboxy-4-hydroxyaniline;Pentasa;Mesalamine;5-Aminosalicylic acid;Mesalazine;Asacol;5-ASA;Salofalk;Claversal;Asacolitin;Salozinal;Mesacol;Asacolon;Fisalamine;Lixacol;Mesasal;m-Aminosalicylic acid;Rowasa;NSC 38877;Canasa;Ipocol;Asalit;Lialda;Mesalsal;Novo-5 ASA;Colasa;Apriso;Mezavant;Rovasa;Fivasa;Delzicol;61513-32-4
CAS No.:89-57-6
Molecular Formula:C7H7NO3
InChIKeys:InChIKey=KBOPZPXVLCULAV-UHFFFAOYSA-N
Molecular Weight:153.14
Exact Mass:153.14
BRN:2090421
EC Number:201-919-1
UNII:4Q81I59GXC
NSC Number:759301|38877
DSSTox ID:DTXSID5024506
NCI Thesaurus Code:C29249
Color/Form:White to pinkish crystals
ATC Code:A07EC02|A - Alimentary tract and metabolism
HScode:2922509090
Categories:
Characteristics-
PSA:
83.6
XLogP3:1.3
Appearance:off-white to gray tablets
Density:1.5±0.1 g/cm3
Melting Point:283 °C
Boiling Point:403.9ºC at 760 mmHg
Flash Point:279-281°C
Refractive Index:1.691
Water Solubility:H2O: <0.1 g/100 mL at 21 ºC;soluble in dimethyl sulfoxide.
Storage Conditions:2-8°C
Vapor Pressure:6.10X10-8 mm Hg at 25 deg C (est)
Toxicity:Peritoneal-mouse LD50: 5000 mg/kg; oral-mouse LDL0: 313 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
Henrys Law Constant:Henry's Law constant = 5.02X10-12 atm-cu m/mol at 25 °C (est)
Dissociation Constants:Mesalamine's production and use in the manufacture of light-sensitive paper, azo and sulfur dyes and as a gastrointestinal medication may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 6.1X10-8 mm Hg at 25 °C indicates mesalamine will exist in both the vapor and particulate phases in the atmosphere. Vapor-phase mesalamine will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 hrs. Particulate-phase mesalamine will be removed from the atmosphere by wet or dry deposition. Mesalamine does contain chromophores that absorb at wavelengths >290 nm and therefore may be expected to be susceptible to direct photolysis by sunlight. If released to soil, mesalamine is expected to have very high mobility based upon an estimated Koc of 10. Estimated pKa values of 2.09, 5.26 and 13.64 indicate that this compound will dissociate to the zwitterion form in the environment. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 5.0X10-12 atm-cu m/mole. Mesalamine is considered completely biodegradable under anaerobic conditions as was indicated by 95.6% methane production following acclimation. If released into water, mesalamine is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to mesalamine may occur through inhalation and dermal contact with this compound at workplaces where mesalamine is produced or used. Use data indicate that the general population may be exposed to mesalamine via dermal contact with products containing this compound as well as via ingestion following administration of drugs containing mesalamine, a gastrointestinal anti-inflammatory. (SRC)
Collision Cross Section:134.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Decomposes at approx 280 °C|Hydroxyl radical reaction rate constant = 2.09X10-11 cu cm/molec-sec at 25 °C (est)
Air and Water Reactions:Sensitive to moisture. Water insoluble.
Reactive Group:Acids, Carboxylic
Reactivity Profile:5-AMINOSALICYLIC ACID is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizers. (NTP, 1992)
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Skin sensitization, Category 1
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P333+P317 If skin irritation or rash occurs: Get medical help.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Commercially available oral mesalamine delayed-release tablets should be stored at a controlled room temperature of 20-25 deg C, while the commercially available oral extended-release capsules should be stored at 25 deg C but may be exposed to temperatures ranging from 15-30 deg C.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Sucralose
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Location:
China jiangsu liyang economic development zone Kang Anlu 1
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Payment Terms:
D/P,L/C
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Average lead Time:
60
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Total Annual Revenue:
Less than $1 million
Jiangsu Giant State Pharmaceutical Co., Ltd. was established in 2011. Located in Liyang Economic Development Zone, Jiangsu Province, China.
Our company specializes in R & D, production and sales of finished products, food additives and APIs. The main products are sucralose, vitamin B1, mesalazine and folic acid.
The sucralose produced and supplied by our company has a good reputation at home and abroad, and has many invention patents. In order to meet the highly developed market demand, we plan to equip two other new production lines every year, about 500 tons per year. Now our company has always been the main supplier. The current sales are nearly 800 million.
Our company strictly implements GMP and ISO quality management systems, and has obtained GMP certification, ISO9001 / ISO22000 / ISO14001 certification, and has passed KOSHER, HALAL, CEP and BRC certification.
We adhere to the principle of self-improvement and social commitment, and pay attention to future challenges. Through unremitting exploration, we strive to become an international company that continuously strives to contribute to human health.
We warmly welcome domestic and foreign merchants to discuss cooperation!
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
India
Mesalazine cas 89-57-6 5-aminosalicylic acid USP42 EP8.6
5 MT Aug 24, 2023 
United States
5-aminosalicylic acid
1 KG Apr 17, 2025 
United Kingdom
5-Aminosalicylic acid 98% solid
40 G May 8, 2026 Post an enquiry for this product
