Estriol 50-27-1

Estriol, a natural hormone, is a metabolite of estradiol in the body, mainly found in urine.  Estrogen is less active, about 6 times the oral activity of estradiol, but weaker than estradiol, no carcinogenic effect, the level of estradiol does not change after taking the drug.  Estriol had selective effects on the vaginal and cervical canals, but had no effect on the uterine body and endometrium.  Animal experiments showed that estriol had a stronger effect on the keratosis of vaginal epithelium than estradiol, and could promote the hyperplasia of vaginal epithelium, keratosis of surface cells, mucosal angiogenesis and healing of vaginal epithelium injury, but had a weaker effect on uterine weight gain in mice.  At the same time, estriol can enhance the function of Chemicalbook cervical cells, make cervical muscle fiber hyperplasia, increase cervical elasticity and softness.  In addition, estriol has a feedback inhibitory effect on hypothalamus and pituitary gland, but does not inhibit ovulation, and only has a significant effect on luteum, so it can be used as an auxiliary drug for mid-term induced labor and induced abortion and the treatment of various menstrual diseases.  Estriol also has a significant effect on hematopoietic system, can reduce the permeability and brittleness of blood vessels, can be used for a variety of bleeding treatment.  It also has the effect of rapidly increasing peripheral white blood cells, which generally begins to take effect 1 ~ 3 days after medication, but the effect time is shorter, and it is effective for leukopenia caused by radiotherapy and chemotherapy.