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Methotrexate

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CAS No.:

59-05-2

Price valid (until):

2026-07-30

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

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Product Description
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Inquiry History

Description

Keywords

Quick Details

ProName:

Methotrexate

CasNo:

59-05-2

Molecular Formula:

C20H22N8O5

Appearance:

Orange or yellow crystalline powder

Application:

Antitumor drugs, for a variety of acute leukemia, chorionic epithelium cell carcinoma, malignant hyd

DeliveryTime:

prompt shipment

PackAge:

25kg/drum

Port:

Hangzhou,Shanghai,China

ProductionCapacity:

Purity:

98.0%~102.0%

Storage:

cool and dry

Transportation:

by sea ,air or express

LimitNum:

1 Kilogram

Superiority

Description: Orange or yellow crystalline powder Identification: IR , UV Water: Not more than 12.0% Residue on ignition :Not more…

Details

Description: Orange or yellow crystalline powder

Identification: IR , UV

Water: Not more than 12.0%

Residue on ignition :Not more than 0.1%

Chromatographic purity:

Total: Not more than 2.0%

Individual: Not more than 0.5%

Specific rotation Between +19°and +24°

Organic volatile impurities:

Ethanol: not more than 0.5%

Aether : not more than 0.5%

Assay :Between 98.0% and 102.0%

Solubility:

practically insoluble in water、chloroform、ethanol and ether, freely soluble in watery alkali, soluble in watery hydrochloric acid

Basic Info

Product Name:

Methotrexate

Other Name:

METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe

CAS No.:

59-05-2

Molecular Formula:

C20H22N8O5

InChIKeys:

FBOZXECLQNJBKD-ZDUSSCGKSA-N

Molecular Weight:

454.44

Exact Mass:

454.44

BRN:

70669

EC Number:

200-413-8

UNII:

YL5FZ2Y5U1

NSC Number:

740

UN Number:

3249

TSCA:

TSCA listed

DSSTox ID:

DTXSID4020822

NCI Thesaurus Code:

C642

Color/Form:

Light yellow to yellow

ATC Code:

L04AX03|L01BA01|L - Antineoplastic and immunomodulating agents

HScode:

29335995

Categories:

Antineoplastic Agents

Characteristics

PSA:

211

XLogP3:

-1.8

Appearance:

powder

Density:

1.4080 (rough estimate)

Melting Point:

195°C

Boiling Point:

561.26°C (rough estimate)

Flash Point:

11℃

Refractive Index:

1.6910 (estimate)

Water Solubility:

Insoluble. <0.1 g/100 mL at 19 ºC

Storage Conditions:

−20°C

Vapor Pressure:

2.1X10-19 mm Hg at 25 deg C /Estimated/

Toxicity:

LD50 oral in rat: 135mg/kg

Specific rotation:

Specific optical rotation: 20.4 + or - 0.6 deg at 21 °C/589 D (concentration by 0.1 N sodium hydroxide) maximum absorption: 243nm, A1= 388;307 nm, A1 = 475 (in 0.1 n hydrogen chloride). 258 nm, A1= 544; 303 nm, A1= 546; 372 nm, A1= 177 (in 0.1 N sodium hydroxide)

PKA:

pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)

Henrys Law Constant:

Henry's Law constant = 1.5X10-31 atm-cu m/mol at 25 °C /Estimated/

Dissociation Constants:

4.7|pKa = 4.70 (carboxylic acid)|pKa = 3.5 carboxylic acid; pKa2 = 8.8, pKa3 = 9.2 (amines) /Estimated/

Collision Cross Section:

196.2 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|194.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Yellow crystals from dilute hydrogen chloride; decomp 185-204 °C (bath preheated to 160 °C). Max absorption (0.1 n hydrogen chloride): 244, 307 nm; max absorption (0.1 N sodium hydroxide): 257, 302, 370 nm; soluble in alkaline solns with decomposition /Methotrexate monohydrate/|Yellow powder; soluble in water. /Methotrexate sodium/|Hydroxyl radical reaction rate constant = 3.2X10-10 cu cm/molec-sec at 25 °C /Estimated/

Air and Water Reactions:

Methotrexate is sensitive to hydrolysis, oxidation and light. Insoluble in water.

Reactive Group:

Acids, Carboxylic

Reactivity Profile:

Methotrexate decomposes in very acidic or alkaline conditions. Methotrexate is incompatible with strong oxidizing agents and strong acids.

Critical Temperature & Pressure:

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

See More Methotrexate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Methotrexate sodium tablets should be protected from light and stored in well-closed containers at 15-30 deg C. Methotrexate sodium injection and powder for injection should be protected from light and stored at 15-30 deg C. Methotrexate sodium

See More Methotrexate Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Location:
1613 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China.

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
7

Total Annual Revenue:
$25 million-$50 million

Total Employees:
11-50

Year of Establishment:
2011

Dawn Ray is a R&D and process improvement company,which is located in Hangzhou, Zhejiang province,China.We are dealing in multi-application of pharmaceuticals(APIs),antibiotics,food additives,peptides and plant extracts.

Dawn Ray has a wide range of products from milligram up to thousands of kilogram quantities.We are also increasing our breed all the time.Our products have been exported all over the world and have a good reputation.

Dawn Ray promises that we can offer you qualified products and excellent service in good prices.Our aim is "Best goods,best service".We sincerely invite customers from all over the world to visit our company,establish business relations and both get win.

Process Capacity: Synthetic,Ferment,extract

After-sale Service:24 hours on skype for business

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	METHOTREXATE IP/BP/USP	1.00 KG	Jul 4, 2025
India	Methotrexate	1.00 KG	Dec 11, 2023

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Methotrexate

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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