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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide

Name: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide
Brand: Boyuan
SKU: pr2203221047
Price: 170 USD
Availability: InStock

Unit Price: Get Latest Price 

CAS No.:

302964-08-5

Content:

99%

Port:

Beijing/Shanghai/Jinan/Qingdao/other importment

Brand:

Boyuan

Packaging:

25kg Carboard Crub

Price valid (until):

2023-12-31

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Shandong Boyuan Pharmaceutical Co., Ltd.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib

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Product Description
Seller Information

Description

Product Detail

Melting point	333-335°C
density	1.516±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly)
form	Solid
pka	10.92±0.70(Predicted)
color	Pale Yellow
InChI	InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)
InChIKey	LMXUWARKUIELGT-UHFFFAOYSA-N
SMILES	S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1
CAS DataBase Reference	302964-08-5(CAS DataBase Reference)

Chemical Properties	Pale Yellow Solid
Uses	Dasatinib intermediate. A protein tyrosine kinase inhibitor.

Introduction

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide appears yellow at room temperature and pressure. Or in the form of light yellow solid powder, it is a polyvalent heterocyclic compound and can be used as an intermediate in organic synthesis.

Solubility

Solubility of N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide in the presence of dimethyl sulfoxide It has certain solubility in methanol and poor solubility in water.

Synthesis

The synthetic method is aimed at the synthesis of N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide, according to literature reports The synthesis method is starting from its precursors 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide and 4,6-dichloro-2-methylpyrimidine in alkaline Under these conditions, the target product can be obtained through the aromatic nucleophilic substitution reaction of the amino group on the pyrimidine ring.

Environmental hazard

N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a nitrogen-containing polybasic Environmental organic compounds are very harmful to the water environment. Do not allow undiluted or large amounts of products to come into contact with groundwater, waterways or sewage systems.

Basic Info

Product Name:

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide

Other Name:

5-Thiazolecarboxamide,N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-;N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide;2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;2007915-37-7

CAS No.:

302964-08-5

Molecular Formula:

C16H13Cl2N5OS

InChIKeys:

InChIKey=LMXUWARKUIELGT-UHFFFAOYSA-N

Molecular Weight:

394.28

Exact Mass:

394.28

EC Number:

695-686-7

DSSTox ID:

DTXSID20460723

HScode:

2934100090

Categories:

Antineoplastics

Characteristics

PSA:

108 Å²

XLogP3:

Density:

1.516±0.06 g/cm3(Predicted)

Melting Point:

333-335°C

Refractive Index:

1.716

See More N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib

Location:
NO.28 SangYuan Rd,JinanCity,ShanDong Province,China

Payment Terms:
TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
1

Total Annual Revenue:
$50 million-$100 million

Total Employees:
501-1000

Year of Establishment:
2005
Country Product Purchase Quantity Date Posted

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