AGOMELATINE, Agomelatine, Valdoxan 98% white powder 138112-76-2 Senwayer

Agomelatine is an atypical antidepressant used to treat major depressive disorder. One review found that it is as effective as other antidepressants with similar discontinuation rates overall but less discontinuations due to side effects. Another review also found it was similarly effective to many other antidepressants.

• Mood Disorders
• 

Agomelatine is used in Europe to treat major depressive episodes. It is also believed to be effective for acute bipolar depression, unipolar and bipolar depression, and even alcohol dependence, as seen in this study.

Today, SSRIs are the commonly used antidepressants because they produce results without too many risks. Agomelatine may be helpful, but without sufficient clinical evidence, it's hard to tell whether they are better than SSRIs. We also don't know how safe they are, especially in the long-term.

• Anxiety Disorder
• 

Agomelatine can be useful in treating depression-related anxiety as well as generalized anxiety disorder. For depression-related anxiety, Agomelatine is more effective as an adjunctive treatment. As seen in this trial, the nootropic isn't just showing great anti-anxiety effects, but it actually performs better than some antidepressant drugs!

In this randomized, double-blind study, patients with Generalized Anxiety Disorder were given 25 to 50mg per day for 12 weeks. The research produced some very interesting results. Scientists observed that the nootropic was very well tolerated. The adverse events experienced were no different from the placebo. They also compared the results to an antidepressant drug Escitalopram and realized the patients taking Escitalopram experienced more adverse events than the people on Agomelatine. In terms of the desired outcomes, it was concluded that Agomelatine was, at the very least, as efficacious as Escitalopram.

These studies are really promising, but they are not of the highest quality. Agomelatine may be as beneficial and safe as reported here, but it may be wiser to hold on from using it until we have bigger and more reliable clinical trials.

• Inflammation

Animal trials report the product can reduce inflammation by deactivating NF-kB and decreasing inflammatory cytokines IL-1beta and IL-6, which are stimulated by Lipopolysaccharides. This makes it a potential treatment for inflammation. It may also aid with metabolic conditions like obesity, insulin resistance, and diabetes.

• Fibromyalgia
• 

The product may be helpful in adjunctive therapies for treating neuropathic pain induced by fibromyalgia. This may be due to the drug's effects on the serotonergic receptor 5-HT2C.

Other benefits linked to Agomelatine include:

• Increased dopamine and norepinephrine boost motivation and mood.
• Increased IGF-1 and Growth Hormone (GH) levels boost sleep quality, muscle strength, bone mineral density, etc.
• Improved synaptic plasticity, which would improve cognitive functions like learning, memory, decision making, etc.

It has has been linked to various side effects that range from mild to severe. Some of the possible mild side effects of the drug are back pain, diarrhea, drowsiness, excessive sweating, fatigue, insomnia, migraines, nausea, anxiety, and constipation.

The drug is also associated with severe side effects like liver damage. It may increase liver enzymes and affect the performance of this vital organ. Some of the symptoms you should watch out for here are light-colored stool, dark urine, and changes in the color of your skin and eyes.

To avoid liver damage, all users should undergo a liver function test before the treatment is started. The tests should be done after every few weeks.

It may also increase the risk of suicide.

Wuhan senwayer century chemical Co.,Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
If you are interested, pls contact me freely!