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Pharmaceutical Powder Factory Export Agomelatine High Purity CAS 138112-76-2

Name: Pharmaceutical Powder Factory Export Agomelatine High Purity CAS 138112-76-2
Brand: Senwayer
SKU: pr2204223731
Price: 8 USD
Availability: InStock

2 Inquiries

Unit Price: Get Latest Price 

CAS No.:

138112-76-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Senwayer

Packaging:

100gram,1KG or under requirement

Price valid (until):

2023-04-02

Contact Supplier

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Pharmaceutical Powder Factory Export Agomelatine High Purity CAS 138112-76-2

Items	Specifications
Product name	Agomelatine
Appearance	White to off-white
Purity	99%
Package	100gram,1KG or under requirement
Grade	Pharma grade

Agomelatine is the world's first melatonin receptor MT1 and MT2 agonist antidepressant. It was developed by the French company Servier and is suitable for the treatment of severe depressive episodes in adult patients. We know that melatonin is an endogenous neurohormone, which is secreted only by the anterior pituitary of the pineal gland at night, and acts on the melatonin receptors concentrated in the suprachiasmatic nucleus (SCN) of the hypothalamus. Participates in mediating the circadian rhythm of mammals. It is a well-known guardian of time in the body and corrects the biological clock regulated by the external circadian cycle. However, due to the high catabolism rate of melatonin in the body, its short half-life and poor selectivity for its receptor located in the SCN have limited its use in the treatment of circadian circadian rhythm disorders. Therefore, in order to overcome these shortcomings of melatonin, the researchers designed a series of melatonin analogs. Molecular model studies show that the indole ring of melatonin is the structural site for catabolism inactivation, so the indole ring becomes an ideal site for isosteric modification. The agomelatine developed by Servier is the biological (electronic) isostere analogue of melatonin. It replaces the indole ring with a nucleus, making it more metabolically stable than melatonin .

Function

1. Promote the activation of the brain, strengthen the brain and improve the intelligence
2. Anti-epileptic, promote sleep
3. Beauty moisturizing, delay brain aging function
4. Lower blood pressure effect
5. Regulate immune function

Product picture

Company information

Our Company located in the predominant WuHan City where is a traffic hinge of China, specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts, and in distributing the products of our own company and affiliated enterprises.

We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.

Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q. A. And Q. C. System, supply chemical products with good quality and custom-tailored products according to our clients′ requirement.

Our advantages

1. Professional sales team.

2. 24hrs online service.

3. 100% Delivery, no customs issues.

4. convenient payment method like : Western union, bank transfer, Bitcoin, USDT,Paypal etc.

5. impeccable After-Sales Service.

Certifications

Packing&Shipping

FAQ

Q1:Can i get free sample ?

A: Yes, most product we can send you small free sample, you just need to pay the shipping cost .

Q2:Which payment method you accept?

A: We accept bank transfer,western union, money gram,bitcoin, USDT,Credit card etc. and more bigger order we accept L/C at sight

Q3: Can i get tracking number after shipment ? and how long does the shipping take?

A: After shipment we will offer you tracking and tell you the website to track the package, usually the shipping time is 3-7days,but for some customers have no ability to declare customs, we use special line route to ship the package, it will take 10-12days to arrive,make sure 100% delivery

Q4: How can you guarantee the quality ?

A: All products we can supply you test report &you can also send our product to the third party to do test, if it is fake,we will full refund you.

ECHEMI Editorial Reference

Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b)Target: 5-HT2C Receptor; 5-HT2B receptorIt is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in
Solid
Agomelatine is a member of acetamides.|Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. The Committee for Medical Products for Human Use (CHMP) recommended refusal of marketing authorization on 27 July 2006. The major concern was that efficacy had not been sufficiently shown. In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis. The development for the US market was discontinued in October 2011. It is currently sold in Australia under the Valdoxan trade name.

Basic Info

Product Name:

Agomelatine

Other Name:

Acetamide,N-[2-(7-methoxy-1-naphthalenyl)ethyl]-;N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide;S 20098;N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;Agomelatine;Valdoxan;N-[2-(7-Methoxynaphthalen-1-yl)ethyl]acetamide;AGO 178;Thymanax

CAS No.:

138112-76-2

Molecular Formula:

C15H17NO2

InChIKeys:

InChIKey=YJYPHIXNFHFHND-UHFFFAOYSA-N

Molecular Weight:

243.30100

Exact Mass:

243.30

UNII:

137R1N49AD

DSSTox ID:

DTXSID3057642

ATC Code:

N06AX22|N - Nervous system

HScode:

2924199090

Categories:

Other Chemical Drugs

Characteristics

PSA:

38.33000

XLogP3:

2.7

Appearance:

white solid

Density:

1.109g/cm3

Melting Point:

109-110 °C @ Solvent: Toluene, Hexane

Boiling Point:

478.8ºC at 760 mmHg

Flash Point:

243.4ºC

Refractive Index:

1.582

Water Solubility:

7.76e-03 g/L

Collision Cross Section:

156.3 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

See More Agomelatine Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H400 Very toxic to aquatic life
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Agomelatine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Agomelatine	30 G	Apr 28, 2026
Sweden	Agomelatine	25 G	Feb 4, 2024

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Pharmaceutical Powder Factory Export Agomelatine High Purity CAS 138112-76-2

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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