Theophylline 99% white powder 58-55-9 Senwayer

Theophylline is a medication used to treat asthma and chronic obstructive pulmonary disease as a second-line drug. It is a bronchodilator. This activity reviews the indications, action, and contraindications for theophylline as a potential agent in treating asthma and chronic obstructive pulmonary disease. This activity will highlight the mechanism of action, adverse event profile, pharmacokinetics, and drug interactions pertinent for members of the interprofessional team in the treatment of patients with asthma and chronic obstructive pulmonary disease.

Medical Uses

Chronic obstructive pulmonary disease
Asthma
Infant Apnea
Anosmia, which is currently under investigation. A clinical study in 2008 reported that theophylline could potentially improve the sense of smell in those with anosmia.

Other uses for this medicine
Theophylline is sometimes used to treat breathing problems in premature infants. Talk to your doctor about the possible risks of using this drug for your baby's condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Theophylline has a very narrow therapeutic window, and its interaction with various other drugs has led to the limitation of its use. The serum theophylline concentrations require monitoring directly to avoid toxicity as the adverse effects of theophylline are related to its plasma concentration and have been observed when plasma concentrations exceed 20 mg/L. Some patients have also experienced adverse effects at low plasma concentrations. The dose gradually increases until achieving therapeutic plasma concentrations. This approach reduces side effects.

The most common side effects are nausea and vomiting, headache, increased stomach acid secretion, and gastroesophageal reflux, which could be due to PDE inhibition. CNS symptoms (irritability, lightheadedness, and dizziness) can also occur in patients. In severe cases, seizures have also occurred. At high serum concentrations, adenosine A1-receptor antagonism could lead to convulsions and cardiac arrhythmias.

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