High Purity 99% Alectinib CAS 1256580-46-7
GMP ISO
1256580-46-7
99%
XAZB
Foil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Description
Product descriptionProduct name:alectinib
CAS:1256580-46-7
Molecular Formula:C30H34N4O2
Molecular Weight:483
EINECS No:821-541-6Specification:99%
Alectinib (CH5424802) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.
Alectinib intermediate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
Specification:
Item
Specification
Appearance
White Crystalline Powder
Assay (HPLC)
99%
Identification
Infrared Absorption
Loss On Drying
≤0.2%
Residue On Ignition
≤0.3%
Chloride
≤0.05%
Sulfate
≤0.03%
Heavy Metals
≤0.0015%
Functions
Alectinib (CH5424802) is an ATP-competitive inhibitor for ALK and L1196M with Ki values of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents autophosphorylation of ALK, and also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 elicits an apoptotic marker-caspase-3/7-like activation-in NCI-H2228 spheroid cells. CH5424802 blocks the growth of two NPM-ALK expressing lymphoma lines, KARPAS-299 and SR with greater efficacy against KARPAS-299 at an IC50 of 3 nM.
CertificatesBasic Info-
Product Name:
Alectinib
Other Name:5H-Benzo[b]carbazole-3-carbonitrile,9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;AF 802;CH 5424802;Alectinib;CH 542480210;RG 7853;RG7853;RG-7853;Alecensa free base;1416163-60-4
CAS No.:1256580-46-7
Molecular Formula:C30H34N4O2
InChIKeys:InChIKey=KDGFLJKFZUIJMX-UHFFFAOYSA-N
Molecular Weight:483
Exact Mass:482.62
EC Number:1592732-453-0
Categories:
Characteristics-
PSA:
72.4
XLogP3:5.2
Density:1.3±0.1 g/cm3
Flash Point:390.7±32.9 °C
Refractive Index:1.673
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Country Product Purchase Quantity Date Posted Post an enquiry for this product