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Alectinib

Alectinib structure

Alectinib 

structure
  • CAS No:

    1256580-46-7

  • Formula:

    C30H34N4O2

  • Chemical Name:

    Alectinib

  • Synonyms:

    5H-Benzo[b]carbazole-3-carbonitrile,9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;AF 802;CH 5424802;Alectinib;CH 542480210;RG 7853;RG7853;RG-7853;Alecensa free base;1416163-60-4

  • Categories:

    Biochemical Engineering  >  Inhibitors

Description

Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM.

Alectinib Basic Attributes

483

482.62

1592732-453-0

Characteristics

72.4

5.2

1.3±0.1 g/cm3

390.7±32.9 °C

1.673

Alectinib Use and Manufacturing

CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.CH5424802 have been clinically evaluated for the treatment of patients with ALK-driven tumors.

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