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99% Pharmaceutical Digestive Antiemetic Domperidone Powder CAS 57808-66-9

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CAS No.:

57808-66-9

Grade:

Pharmaceutical Grade

Content:

Brand:

Packaging:

Foil Bag, Box, Drum

Sample Available:

Yes

Price valid (until):

2022-12-31

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Xian ZB Biotech Co.,Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

8 days

Qualification:

Main Products:

Herb Extracts,Cosmetic raw materails,API

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Product Description
Seller Information
Inquiry History

Description

_Domperidone
_{CAS No.:}	_57808-66-9
_Synonyms:	_{6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;}
_Formula:	_C22H24ClN5O2
_{Exact Mass:}	_425.16200
_{Molecular Weight:}	_425.91100
_PSA:	_78.82000
_LogP:	_3.29110
_Appearance	_{white powder}
_Density:	_{1.341 g/cm3}
_{Melting Point:}	_242.5ºC
_Stability:	_{Stable. Incompatible with strong oxidizing agents.}
_{Storage Condition:}	_{Keep tightly closed.}

_{A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.}
_{Domperidone is a commonly used antiemetic and gastro-kinetic drug with its appearance being white to light yellow powder and bitter taste. It is almost insoluble in water, slightly soluble in ethanol, easily soluble in lactic acid as well as soluble in citrate. This product is a kind of peripheral dopamine receptor antagonists with strong action.}
_{Domperidone can block the DA1 and DA2 receptor next to the synapses, antagonizing the inhibitory effect of dopamine on the postsynaptic cholinergic neurons of myenteric plexus and causing the stomach contractions. It can promote the motility and tension of digestive tract motility to return to normal function, promoting the emptying of stomach, increasing the motility of gastric antral and duodenum, coordinating the contraction of the pylorus as well as enhancing the esophageal peristalsis and the tension of the lower esophageal sphincter.\}

99% Pharmaceutical Digestive Antiemetic Domperidone Powder CAS 57808-66-9

_{1. Gastrointestinal problems
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.
It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood-brain barrier.
Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".
2. Lactation
The hormone prolactin stimulates lactation in humans, and its release is inhibited by the dopamine secreted by the hypothalamus. Domperidone, by acting as an anti-dopaminergic, results in increased prolactin secretion, and thus promotes lactation

COA of Domperidone Powder :}

_Items	_Requirements	_Results
_Appearance	_{White to off white powder}	_{White powder}
_Solubility	_{Practically insoluble in water, soluble in dimethylformamide,} _{slightly soluble in ethanol(96%) and in meth}	_Confirms
_{Identification}	_{A. M.P. 244~248ºC}	_{244.5~245.5ºC}
	_{B. IR should comply}	_Confirms
	_{C. TLC should comply}	_Confirms
	_{D. It gives the reaction of non-nitrogen substituted barbiturates.}	_Confirms
_{Clarity of solution}	_{The solution is clear and not more intensely colored than} _{reference solution Y6}	_Confirms
_{Related substance}	_{Total impurities≤0.5%}	_≤0.29%
_{Related substance}	_{Individual impurity≤0.25%}	_≤0.18%
_{Loss on drying}	_≤0.5%	_0.07%
_{Sulphated ash}	_≤0.1%	_≤0.05%
_{Heavy metal}	_≤20ppm	_<20ppm
_Assay	_99.0%~101.0%	_99.49%

99% Pharmaceutical Digestive Antiemetic Domperidone Powder CAS 57808-66-9

ECHEMI Editorial Reference

Domperidone is a dopamine blocker and an antidopaminergic reagent.Target: Dopamine ReceptorDomperidone is a useful alternative to metoclopramide for treatment of gastroparesis due to better tolerability. Effectiveness and side-effects from domperidone may be influenced by patient-related factors including polymorphisms in genes encoding drug-metabolizing enzymes, drug transporters, and domperidone targets [1]. Domperidone is a dopamine D(2) receptor antagonist, which has been used as ant
Solid
Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine.|A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.|Domperidone is a peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.

Certificates

Basic Info

Product Name:

Domperidone

Other Name:

2H-Benzimidazol-2-one,5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-;5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one;Domperidone;Motilium;KW 5338;R 33812;Nauzelin;Nauzelin Ds;Mod;Peridys;Gastronorm;Euciton;Peridon;Evoxin;NSC 299589;Motillium;Motinorm costi;Nomit;Domperi 10 DT;Domcolic

CAS No.:

57808-66-9

Molecular Formula:

C22H24ClN5O2

InChIKeys:

InChIKey=FGXWKSZFVQUSTL-UHFFFAOYSA-N

Molecular Weight:

425.91100

Exact Mass:

425.91

EC Number:

260-968-7

UNII:

5587267Z69

NSC Number:

759575|299589

DSSTox ID:

DTXSID1045116

NCI Thesaurus Code:

C454

ATC Code:

A03FA03|A - Alimentary tract and metabolism

HScode:

2933990090

Categories:

Digestive System Drugs

Characteristics

PSA:

78.82000

XLogP3:

3.29110

Appearance:

Solid

Density:

1.341 g/cm3

Melting Point:

242.5 °C

Boiling Point:

723.6±70.0 °C at 760 mmHg

Flash Point:

391.4±35.7 °C

Refractive Index:

1.729

Water Solubility:

Slightly soluble in water.

Storage Conditions:

Keep tightly closed.

PKA:

7.9None

Dissociation Constants:

7.9

Collision Cross Section:

201.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Domperidone Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Domperidone Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Herb Extracts,Cosmetic raw materails,API

Location:
1403,Jinye B Block

Payment Terms:
TT against copy of documents

Average lead Time:
8 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2015

Xian ZB Biotech Co.,Ltd is a leading Manufactory supplier of Arbutin, Nicotinamide, Flucytosine based in Xi'an, Shaanxi, China. With a commitment to quality and customer satisfaction, Xian ZB Biotech Co.,Ltd has become a trusted name in the industry. Our product line includes a range of high-quality Arbutin, Nicotinamide, Flucytosine, which are available at competitive prices. Xian ZB Biotech Co.,Ltd has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Domperidone USP	25 KG	Oct 10, 2024

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99% Pharmaceutical Digestive Antiemetic Domperidone Powder CAS 57808-66-9

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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