Pyridoxal-5-phosphate, P5P 99% white powder 54-47-7 Senwayer

Pyridoxal phosphate, the active form of vitamin B₆, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities.

Vitamin B6 Deficiency
A P5P deficiency can cause problems in the nerves, skin and blood. Anemia (a lack of iron in your blood) is one possibility. Signs of pyridoxine deficiency include diarrhea, rash and even dementia. Nausea and vomiting may also occur, leading to poor appetite and possibly malnutrition. Confusion, depression and anxiety are other potential indicators.  The American College for Advancement of Medicine reported that a deficiency in B6 and iron causes panic attacks and anxiety in their newsletter. The report stems from a human study performed in Japan, supporting low levels of B6 and iron results in anxiety and panic attacks. 

Low levels of P5P may cause peripheral neuropathy—pain, numbness and weakness around the body. Some other symptoms include insomnia, soreness on the tongue and irritability.

Decreased immunity can become a problem with a deficiency of pyridoxine. Children may experience a form of epilepsy if their bodies cannot metabolize Vitamin B6. A P5P supplement may alleviate many or all of these symptoms and reverse a deficiency.

Sideroblastic Anemia
Sideroblastic anemia is a group of blood disorders in which the bone marrow does not produce healthy red blood cells because of an inability to convert iron into hemoglobin. The iron accumulates in the red blood cells, creating a ringed sideroblast or a ringed nucleus in the cell. Symptoms include fatigue, weakness, trouble breathing, and an enlarged spleen and liver. Though you can inherit this health concern, other conditions can cause it as well, such as drug and toxin exposure. The cause may also be idiopathic or unknown.  In certain instances, a P5P supplement may help. According to a research study, the supplement helped alleviate the symptoms in a 72-year-old patient.

Homocysteine Blood Levels
High levels of the amino acid homocysteine mean potential risk factors for cardiovascular disease.It stems from your body generating the amino acid methionine when you ingest meat, mainly. Researchers have found a correlation between high homocysteine levels and heart disease. 

P5P supplements may reduce methionine levels in the body, reducing homocysteine levels at the same time. P5P may also help protect against high blood pressure (hypertension), coronary heart disease and cerebral vascular disease. 

Cancer
A P5P deficiency may increase the risk for cancer of the cervix and pancreas. Studies show that many women with cervical cancer are deficient in Vitamin B6. Researchers need to conduct more studies, but because there is a connection between the two, P5P supplements may reduce the risk for cervical cancer.

Pancreatic cancer is less common than other types, but it is very aggressive and kills an estimated 45,000 Americans in 2019. One study further revealed that a full quarter of pancreatic cancer patients were deficient in Vitamin B6 and that subjects who consumed higher levels of Vitamin B6 — either from their diet or from supplements—had a reduced risk for pancreatic cancer.

Vision
Age-related macular degeneration (AMD) is an increasingly common disorder that causes vision loss, mainly in people older than 50. The macula is a small spot near the middle of the retina, which is necessary for clear central vision. AMD may progress slowly, or it may move fast. Studies claim that P5P supplements with other B vitamins may prevent vision loss from macular degeneration. 

Arterial Health
Coronary heart disease is the number one killer in both men and women in the United States. It stems from plaque building up in the arteries. Atherosclerosis is a condition in which the arteries harden and lose flexibility. (x) According to research studies, B vitamin supplements, including P5P, may reduce the progression of early atherosclerosis.

Kidney Stones
Certain people have a higher likelihood of developing kidney stones because of a genetic disorder called type I primary hyperoxaluria.  Some research indicates that a B6 supplement with or without magnesium may decrease the risk of kidney stones for those with this inherited condition. However, it’s vital to note that Vitamin B6 does not seem to help those who have developed kidney stones because of other causes.

Nausea During Pregnancy
Studies suggest that taking Vitamin B6 in the form of pyridoxine may reduce nausea and vomiting for pregnant women. In fact, the American College of Obstetrics and Gynecology recommends Vitamin B6 first as a treatment for this complaint in early pregnancy.

Tardive Dyskinesia
Tardive dyskinesia is a movement disorder in which the muscles of the face, neck, and limbs twitch involuntarily and interfere with the ability to communicate. It is a side effect of antipsychotic drugs used to treat schizophrenia — these drugs incapacitate you when you take them. Studies show that P5P supplements may help improve symptoms of this condition in some patients. However, the claim requires more research or avoid taking psychotropic drugs. 

Aging
Glycation is a process in which sugar attaches to protein and forms harmful new molecules called advanced glycation end products (AGE).  Cataracts are one example of glycation; poor kidney function is another.  AGEs can affect collagen production, causing premature aging. Wrinkled, sagging skin is one of the most visible signs. Studies suggest that Vitamin B6 may help protect against the glycation process and inhibit AGE formation. 

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