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Pharmaceutical Intermediates CAS 38183-03-8 Raw Material 7, 8-Dihydroxyflavone High Purity

Name: Pharmaceutical Intermediates CAS 38183-03-8 Raw Material 7, 8-Dihydroxyflavone High Purity
Brand: Senwayer
SKU: pr2304201795
Price: 5 USD
Availability: InStock

11 Inquiries

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CAS No.:

38183-03-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Senwayer

Packaging:

100gram,1KG or under requirement

Price valid (until):

2023-04-02

Contact Supplier

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Pharmaceutical Intermediates CAS 38183-03-8 Raw Material 7, 8-Dihydroxyflavone High Purity

Items	Specifications
Product name	7,8-Dihydroxyflavone
Appearance	Yellow powder
Purity	99%
Package	100gram,1KG or under requirement
Grade	Pharma grade

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally bioavailable and able to penetrate the blood-brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.

Function

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).

7,8-DHF is both orally bioavailable and able to penetrate the blood-brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.

Product picture

Company information

Our Company located in the predominant WuHan City where is a traffic hinge of China, specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts, and in distributing the products of our own company and affiliated enterprises.

We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.

Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q. A. And Q. C. System, supply chemical products with good quality and custom-tailored products according to our clients′ requirement.

Our advantages

1. Professional sales team.

2. 24hrs online service.

3. 100% Delivery, no customs issues.

4. convenient payment method like : Western union, bank transfer, Bitcoin, USDT,Paypal etc.

5. impeccable After-Sales Service.

Certifications

Packing&Shipping

FAQ

Q1:Can i get free sample ?

A: Yes, most product we can send you small free sample, you just need to pay the shipping cost .

Q2:Which payment method you accept?

A: We accept bank transfer,western union, money gram,bitcoin, USDT,Credit card etc. and more bigger order we accept L/C at sight

Q3: Can i get tracking number after shipment ? and how long does the shipping take?

A: After shipment we will offer you tracking and tell you the website to track the package, usually the shipping time is 3-7days,but for some customers have no ability to declare customs, we use special line route to ship the package, it will take 10-12days to arrive,make sure 100% delivery

Q4: How can you guarantee the quality ?

A: All products we can supply you test report &you can also send our product to the third party to do test, if it is fake,we will full refund you.

ECHEMI Editorial Reference

7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1].
Pale yellow powder; Bland aroma
7,8-dihydroxyflavone is a dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's. It has a role as a plant metabolite, a tropomyosin-related kinase B receptor agonist, an antidepressant, an antioxidant and an antineoplastic agent.

Research & Reference Note

Pharmaceutical Intermediates CAS 38183-03-8 Raw Material 7, 8-Dihydroxyflavone High Purity is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Basic Info

Product Name:

7,8-Dihydroxyflavone

Other Name:

4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-;Flavone,7,8-dihydroxy-;7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one;7,8-Dihydroxyflavone;7,8-Dihydroxy-2-phenyl-4H-chromen-4-one

CAS No.:

38183-03-8

Molecular Formula:

C15H10O4

InChIKeys:

InChIKey=COCYGNDCWFKTMF-UHFFFAOYSA-N

Molecular Weight:

254.24

Exact Mass:

254.24

EC Number:

253-812-4

UNII:

ADB6MA8ZV2

NSC Number:

750341

DSSTox ID:

DTXSID00191568

HScode:

2914400090

Categories:

Other Chemical Drugs

Characteristics

PSA:

66.8

XLogP3:

3.3

Density:

1.4±0.1 g/cm3

Melting Point:

240-242 °C

Boiling Point:

494.4°C at 760 mmHg

Flash Point:

193.5±22.2 °C

Refractive Index:

1.699

Water Solubility:

DMSO: soluble 24mg/mL

Storage Conditions:

Store at +4°C

Collision Cross Section:

152 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More 7,8-Dihydroxyflavone Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 7,8-Dihydroxyflavone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

11 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	7,8-Dihydroxyflavone	75.00 G	Aug 14, 2024
Australia	7,8-Dihydroxyflavone	10 G	Oct 17, 2026
Russia	Sofosbuvir	68.00 G	Aug 14, 2024
Russia	Citicoline sodium	750.00 G	Aug 14, 2024
Russia	PRL-8-53	10.00 G	Aug 14, 2024
Russia	Enclomiphene	100.00 G	Aug 14, 2024
Russia	Velpatasvir	17.00 G	Aug 14, 2024
Russia	NNMTi	15.00 G	Aug 14, 2024
Russia	Unifiram	30.00 G	Aug 14, 2024
Russia	Coluracetam	100.00 G	Aug 14, 2024
Russia	DIHEXA	50.00 G	Aug 14, 2024

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Pharmaceutical Intermediates CAS 38183-03-8 Raw Material 7, 8-Dihydroxyflavone High Purity

Product Description

Seller Information