ASTX660
1799328-86-1
Industrial Grade
99%
Dideu
25kg/Cardboard Drum
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceASTX660 is under investigation in clinical trial NCT02503423 (Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas).|Tolinapant is an orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptotic activities. Upon administration, tolinapant selectively binds to and inhibits the activity of XIAP and cIAP1. This restores and promotes the induction of apoptotic signaling pathways in cancer cells, and inactivates the nuclear factor-kappa B (NF-kB)-mediated survival pathway. XIAP and cIAP1 are overexpressed by many cancer cell types and suppress apoptosis by inhibiting the activity of certain caspases; they promote both cancer cell survival and chemotherapy resistance.Basic Info
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Product Name:
1-(6-(4-Fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one
Other Name:ASTX660;1799328-86-1;ASTX-660;UNII-2LHZ9ZC3YO;2LHZ9ZC3YO;CHEMBL4173974;1799328-86-1 (free base);1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one;Tolinapant;ASTX 660
CAS No.:1799328-86-1
Molecular Formula:C30H42FN5O3
InChIKeys:YCXOHEXZVKOGEV-DNRQZRRGSA-N
Molecular Weight:539.7
Exact Mass:539.32716838
UNII:2LHZ9ZC3YO
NCI Thesaurus Code:C123913
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
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