Sinapultide 98% white powder CAS 138531-07-4/ Youngshe
138531-07-4
Chemical Grade
98%
chengdu
Youngshe
Plastic bottle
Yes
2030-12-30
Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediates
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceSinapultide (also known as KL4 peptide) is a synthetic protein used to mimic human lung surfactant protein B. This protein has a weight of 2469.40. Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the sequence KLLLLKLLLLKLLLLKLLLLK (KL4), in aqueous dispersion with the phospholipids DPPC (dipalmitoylphosphatidylcholine), POPG (palmitoyloleoyl-phosphatidylglycerol), and palmitic acid, to create the drug [lucinactant]. The product was originally developed by the Scripps Research Institute, then licensed to Windtree Therapeutics. Windtree Therapeutics plans a phase III trial for Respiratory distress syndrome in 2018. Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in preterm infants. Surfactant replacement therapy has been commonly used to prevent and treat RDS in these newborns and is now a standard of care. First-generation synthetic surfactants that were previously used, such as Exosurf did not contain any surfactant protein. This large disadvantage was overcome with animal-derived surfactant products which contain specific proteins but are limited, but must be derived from animal sources. This has led to the development of newer synthetic surfactants such as lucinactant (Surfaxin), which contains sinapultide. Phase 3 clinical trials with Surfaxin show promising results with similar efficacy as animal-derived surfactants while avoiding the use of animal-origin products. Windtree is currently developing aerosolized KL4 surfactant to treat RDS in premature infants, and thereafter, to potentially address a range of indications in neonatal, pediatric and adult critical care patient populations.Basic Info
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Product Name:
Sinapultide
Other Name:sinapultide;KL4 (peptide);UNII-040X3AX99T;ATI 01;040X3AX99T;Sinapultide [USAN:INN];RWJ 45652;SCHEMBL180504;CHEMBL2103901
CAS No.:138531-07-4
Molecular Formula:C126H238N26O22
InChIKeys:QSIRXSYRKZHJHX-TWXHAJHVSA-N
Molecular Weight:2469.4
Exact Mass:2468.83375816
UNII:040X3AX99T
DSSTox ID:DTXSID30160707
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediates
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Location:
Unit 12, Building 10, No.77, Tianmu Road, Gaoxin West District, Yi County, Chengdu City, Sichuan Province
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Payment Terms:
TT against copy of documents
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2015
Company Certificates-
ISO9001
Chengdu YoungShe Chemical Co., Ltd is a new and dynamic high-tech enterprise that is constantly innovating and specializing in the development of beauty peptides. The company is headquartered in Chengdu Hi-tech Development Zone. Since its establishment in early 2015, the company has launched hundreds of beauty peptide products with different functions, which are widely sold at home and abroad.
Chengdu Youngshe Chemical Co., Ltd.'s main cosmetic peptide products are dipeptide, tripeptide, tetrapeptide, pentapeptide, hexapeptide, and seven peptides ( heptapeptide, octapptide, nonapeptide, decapeptide, and oligopeptide.
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