Abiraterone
154229-19-3
99%
Bottle,barrel,cargo,container,etc.
Yes
2026-10-24
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Product Description
-
Seller Information
-
DescriptionKeywords
Abiraterone
154229-19-3
C24H31NO
Quick DetailsProName:Abiraterone
CasNo:154229-19-3
Molecular Formula:C24H31NO
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceAbiraterone is a potent, selective, and irreversible CYP17 inhibitor with IC50 of 2 to 4 nM.
Abiraterone is a 3beta-sterol that is androsta-5,16-dien-3beta-ol substituted at position 17 by a 3-pyridyl group. Administered as the O-acetate, it is used for treatment of metastatic castrate-resistant prostate cancer. It has a role as an antineoplastic agent and an EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor. It is a 3beta-sterol and a member of pyridines. It derives from a hydride of an androstane.|Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.|Abiraterone is a Cytochrome P450 17A1 Inhibitor. The mechanism of action of abiraterone is as a Cytochrome P450 17A1 Inhibitor, and Cytochrome P450 2D6 Inhibitor, and Cytochrome P450 2C8 Inhibitor.|Abiraterone is a Cytochrome P450 17A1 Inhibitor. The mechanism of action of abiraterone is as a Cytochrome P450 17A1 Inhibitor.|Abiraterone is an antiandrogen used to treat metastatic, castration-resistant prostate cancer. Abiraterone is associated with a not uncommon rate of serum enzyme elevation during therapy, but has not been clearly linked to cases of clinically apparent liver injury with jaundice.|Abiraterone is a steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.Basic Info-
Product Name:
Abiraterone
Other Name:Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-,(3β)-;(3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol;CB 7598;Abiraterone;17-(3-Pyridinyl)-androsta-5,16-dien-3β-ol
CAS No.:154229-19-3
Molecular Formula:C24H31NO
InChIKeys:InChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N
Molecular Weight:349.51
Exact Mass:349.51
EC Number:1308068-626-2
UNII:G819A456D0
NSC Number:749226
NCI Thesaurus Code:C77333
ATC Code:L02BX03|L - Antineoplastic and immunomodulating agents
HScode:2933399090
Categories:
Characteristics-
PSA:
33.1
XLogP3:5.70
Appearance:white solid
Density:1.14g/cm3
Melting Point:227-228 °C @ Solvent: Toluene
Boiling Point:500.2±50.0 °C at 760 mmHg
Flash Point:256.3±30.1 °C
Refractive Index:1.606
Vapor Pressure:7.99E-11mmHg at 25°C
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
-
Payment Terms:
TT against copy of documents,D/P,L/C
-
Average lead Time:
5 days
-
Total Annual Revenue:
Above $100 million
-
Year of Establishment:
2020
Company Certificates-
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
More from this Seller
-
-
![1-(4-CHLOROPHENYL)ETHANONE OXIME]( "1-(4-CHLOROPHENYL)ETHANONE OXIME")
-
1-(4-CHLOROPHENYL)ETHANONE OXIME
/ 99.00%
-
-
-
![(Z)-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE]( "(Z)-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE")
-
(Z)-1,1,1,4,4,4-HEXAFLUORO-2-BUTENE
/ 99.00%
-
-
-
![4-Bromochlorobenzene]( "4-Bromochlorobenzene")
-
4-Bromochlorobenzene
/ 99.00%
-
-
-
![1,4-Dioxan-2-one]( "1,4-Dioxan-2-one")
-
1,4-Dioxan-2-one
/ 99.00%
-
-
-
![N-acetyl serotonin]( "N-acetyl serotonin")
-
N-acetyl serotonin
/ 99.00%
-
