PHORBOL 12-MYRISTATE 13-ACETATE
16561-29-8
99%
Bottle,barrel,cargo,container,etc.
Yes
2026-11-24
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Details
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Seller Information
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DescriptionKeywords
PHORBOL 12-MYRISTATE 13-ACETATE
16561-29-8
C36H56O8
Quick DetailsProName:PHORBOL 12-MYRISTATE 13-ACETATE
CasNo:16561-29-8
Molecular Formula:C36H56O8
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial Reference12-o-tetradecanoylphorbol-13-acetate appears as white crystals. (NTP, 1992)
12-o-tetradecanoylphorbol-13-acetate appears as white crystals. (NTP, 1992)|Phorbol 13-acetate 12-myristate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. It has a role as a protein kinase C agonist, an antineoplastic agent, a reactive oxygen species generator, a plant metabolite, a mitogen, a carcinogenic agent and an apoptosis inducer. It is an acetate ester, a tetradecanoate ester, a diester, a tertiary alpha-hydroxy ketone and a phorbol ester.|Tetradecanoylphorbol Acetate is a phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)|A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.Basic Info-
Product Name:
Phorbol 12-myristate 13-acetate
Other Name:Tetradecanoic acid,(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester;Myristic acid,9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate,(+)-;Tetradecanoic acid,9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester,[1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-;1H-Cyclopropa[3,4]benz[1,2-e]azulene,tetradecanoic acid deriv.;13-O-Acetylphorbol 12-myristate;Phorbol myristate acetate;12-O-Tetradecanoylphorbol 13-acetate;Factor A1 (croton oil);12-Tetradecanoylphorbol 13-acetate;Tetradecanoylphorbol acetate;Phorbol 12-tetradecanoate 13-acetate;Phorbol 12-myristate 13-acetate;TPA;Factor A1;PMA;4β-Phorbol 12-myristate 13-acetate;PMA (tumor promoter);β-Phorbol 12-myristate 13-acetate;12-Tetradecanoylphorbol 13-monoacetate;TPA (phorbol derivative);NSC 262244;PD 616;11016-13-0;11019-85-5;20839-11-6;26894-58-6;27534-73-2;51898-14-7
CAS No.:16561-29-8
Molecular Formula:C36H56O8
InChIKeys:InChIKey=PHEDXBVPIONUQT-RGYGYFBISA-N
Molecular Weight:616.82500
Exact Mass:616.83
EC Number:605-413-5
UNII:NI40JAQ945
NSC Number:626496|262644
UN Number:2811
DSSTox ID:DTXSID5023798
NCI Thesaurus Code:C866
Color/Form:Oil|White crystals|Colorless powder|Amorphous film, solid
Categories:
Characteristics-
PSA:
130.36000
XLogP3:5.75290
Appearance:White to off-white solid.
Density:1.17 g/cm3
Melting Point:162 °F (NTP, 1992)|50-70 °C (melting pt-freezing pt)
Boiling Point:698.1ºC at 760 mmHg
Flash Point:208.1ºC
Refractive Index:1.553
Water Solubility:Practically insoluble (NTP, 1992)|Insoluble in water|Soluble in DMSO (25 mg/mL), 100% ethanol (25 mg/mL), acetone, ether, DMF, methanol, and chloroform; insoluble in aqueous buffers
Storage Conditions:-20ºC
Vapor Pressure:1.55E-22mmHg at 25°C
Henrys Law Constant:Henry's Law constant = 4.7X10-12 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa 12.6 at 25 °C (est)
Experimental Properties:Sensitive to acids and alkalis|Protect from light|Hydroxyl radical reaction rate constant = 2.1X10-10 cu cm/molecule-sec at 25 °C (est)
Air and Water Reactions:Practically water insoluble.
Reactive Group:Alcohols and Polyols
Reactivity Profile:12-O-TETRADECANOYLPHORBOL-13-ACETATE is sensitive to acids and alkalis. (NTP, 1992).
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5 days
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
Company Certificates-
![HANGZHOU LEAP CHEM CO., LTD.ISO]( "ISO")
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
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