Daunorubicin 99% Dideu-5-00472 Dideu
20830-81-3
Pharmaceutical Grade
99%
Dideu
25kg/Cardboard Drum
Yes
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceDaunorubicin is a topoisomerase II inhibitor.
Anthracycline antibiotic. An anticancer agent.|Solid
Anthracycline antibiotic. An anticancer agent.|Daunorubicin is a natural product found in Actinomadura roseola. It has a role as an antineoplastic agent and a bacterial metabolite. It is an anthracycline, a member of tetracenequinones, a member of p-quinones and an aminoglycoside antibiotic. It is a conjugate base of a daunorubicin(1+). It derives from a hydride of a tetracene.|A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.|Daunorubicin is an Anthracycline Topoisomerase Inhibitor. The mechanism of action of daunorubicin is as a Topoisomerase Inhibitor.|Daunorubicin is an anthracycline antibiotic that has antineoplastic activity and is used in the therapy of acute leukemia and AIDS related Kaposi sarcoma. Daunorubicin is associated with a low rate of transient serum enzyme and bilirubin elevations during therapy, but has not been implicated in cases of clinically apparent acute liver injury with jaundice.|Daunorubicin is an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.|A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.Basic Info-
Product Name:
Daunorubicin
Other Name:5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S,10S)-;Daunomycin;5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,(8S-cis)-;(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione;Rubomycin C;Daunorubicin;Daunorubicine;NSC 82151;RP 13057;Rubidomycin;Acetyladriamycin;Cerubidin;Leukaemomycin C;(+)-Daunomycin;Daunomycine;DaunoXome;NSC 83142;Daunoblastina;(7S,9S)-9-Acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,l 1-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;FSL 0507;1407-15-4;11006-54-5;11048-29-6;23942-76-9;27576-81-4;28020-80-6;149541-57-1;182250-71-1;1088231-28-0;1263312-57-7
CAS No.:20830-81-3
Molecular Formula:C27H29NO10
InChIKeys:InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N
Molecular Weight:527.52
Exact Mass:527.52
EC Number:245-723-4
UNII:ZS7284E0ZP
NSC Number:756717
DSSTox ID:DTXSID7022883
NCI Thesaurus Code:C62091
Color/Form:Reddish needles|Thin, red needles
ATC Code:L01DB02|L - Antineoplastic and immunomodulating agents
Categories:
Characteristics-
PSA:
186
XLogP3:0.1
Density:1.6±0.1 g/cm3
Melting Point:208-209 °C
Boiling Point:190 deg C, decomposes
Flash Point:419.5±32.9 °C
Refractive Index:1.692
Water Solubility:6.27e-01 g/L
Storage Conditions:Commercially available daunorubicin citrate liposomal injection should be refrigerated at 2-8 deg C and protected from light and freezing; the shelf-life of the injection is 24 weeks when stored as recommended. When diluted as directed with dextrose 5% injection, solutions of daunorubicin citrate liposomal injection are stable for up to 6 hours when refrigerated at 2-8 deg C.
Vapor Pressure:9.4X10-15 mm Hg at 25 deg C
Toxicity:Oral-Rat LD50 336 mg/kg; Oral-Mouse LD50: 205 mg/kg
Flammability characteristics:Open flame, heat, oxidant is combustible; burning emits nitrogen oxides to stimulate smoke
Henrys Law Constant:Henry's Law constant = 2.18X10-13 atm-cu m/mol at 26 °C
Dissociation Constants:pKa = 7.85
Collision Cross Section:222.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:The aglycone can be reduced by sodium borohydride; subsequent periodate oxidation yields benzaldehyde.|Aqueous solutions are stable for one month at 5 °C; unstable at higher temperatures or at acid or alkaline pH's.|Hydroxyl radical reaction rate constant = 1.4X10-10 cu cm/molec-sec at 25 °C (est)
Air and Water Reactions:No rapid reaction with air. No rapid reaction with water.
Reactive Group:Amines, Phosphines, and Pyridines
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H341 Suspected of causing genetic defects
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
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