99%Erythromycin

Product：

Erythromycin

CAS：

114-07-8

molecular formula：

C37H67NO13

molecular weight：

733.93

melting point

133 °C

frezeeing

86℃

specific rotation

D24 -90.4° (c = 1 in CHCl3)

density

1.1334 (rough estimate)

refractive index

-92 ° (C=1, CHCl3)

flashing point

>110°(230°F)

Storage

-20°C

solubility

Soluble in DMSO

acid(pKa)

pKa 8.99(H2O t=25.0 I=0.167) (Uncertain)

appearance

powder

colour

colorless to faint yellow

water solubility

99.48mg/L(20 ºC)

Merck

14,2339

BCS Class

4

stability

Store in Freezer

InChIKey

AGOYDEPGAOXOCK-KCBOHYOISA-N

Founded in 2008, East Chemsources Limited is a professional manufacturer of supplier in food and beverage, pharmaceuticals, cosmetics and other industries.  Through more than four years development, our company has developed from single product at first to providing solution to finished products now, is committed to providing solutions for success and growth through long term relationships. 

Currently, our products have been exported to more than 50 countries all over the world. Our service is accomplished by providing good quality solution that matches the specifications of our clients at competitive price. Our products will derive from trusted sources and arrive to our clients in time and well arranged manner, be creating the greatest benefits for our customers. 

Whether your project is large or small, whether it needs one, several or all of our disciplines you will find our level of dedication to a quality result to be the same. We are looking forward to your sincere cooperation and participation. 

Our advantages:

1. High quality with the competitive price.

2. Professional and experienced business services.

3. Prompt delivery within 2-3 weeks (1 weeks is available for ready stock)

4. Quick response to client inquiries

5. Free samples and shipping documents in accordance with the regulations of different countries

6. Adequate product inventory

6. Variety of payments, such as L/C, TT, , MoneyGram or other payments.

Erythromycin is taken orally 200 ~ 250mg, and the blood concentration reaches a peak after 2 ~ 3h, generally less than 1μg/mL. After drug absorption, in addition to cerebrospinal fluid and brain tissue, it is widely distributed in various tissues and body fluids, especially in the liver, bile and spleen (the concentration in bile can reach 10 to 40 times the blood concentration). The concentration of drug in kidney, lung and other tissues can be several times higher than that in blood. There is also a high concentration in subcutaneous tissue, sputum and bronchial secretions (sputum concentration is similar to blood concentration); The concentration in chest, peritoneal effusion and pus can reach the effective bacteriostatic concentration. Erythromycin can have a certain amount (about 33% of the blood concentration) into the prostate and seminal vesicles, but it is not easy to penetrate the blood-cerebrospinal fluid barrier, and the cerebrospinal fluid concentration is only about 10% of the blood concentration when there is inflammation of the meninges. Erythromycin can enter the fetal blood circulation and breast milk, the fetal blood concentration is 5% to 20% of the maternal blood concentration, and the breast milk can reach more than 50% of the blood concentration. After oral administration of erythromycin with different salts, the bioavailability is about 30% ~ 65%. The apparent volume of distribution is 0.9L/kg. The protein binding rate was 70% ~ 90%. The half-life is about 1.4 ~ 2.0h, and the half-life of anuria patients can be extended to 4.8 ~ 6.0h. Free erythromycin is metabolized in the liver, mainly concentrated in the liver and excreted from the bile. About 2% to 5% of the oral dose and 10% to 15% of the injected dose are excreted in urine through glomerular filtration in their original form. The concentration in urine can reach 10-100 μg/mL. In addition, stool also contains a certain amount of drugs. Peritoneal dialysis and hemodialysis are not effective in clearing erythromycin. Erythromycin lactobionate is a water-soluble erythromycin lactobionate, which reaches its peak concentration after intravenous infusion. The mean blood concentration of 2g was 2.3 ~ 6.8mg/L after intravenous infusion within 24 hours. After absorption, the drug was widely distributed in all tissues and body fluids except cerebrospinal fluid and brain tissue, especially in liver, bile and spleen. The concentration of drug in kidney, lung and other tissues can be several times higher than that in blood. There is also a high concentration in subcutaneous tissue, sputum and bronchial secretions (sputum concentration is similar to blood concentration); The concentration in chest, peritoneal effusion and pus can reach the effective bacteriostatic concentration. Erythromycin can enter the fetal blood circulation and breast milk, but it does not easily cross the blood-cerebrospinal fluid barrier. Free erythromycin is mainly metabolized in the liver, concentrated in the liver, excreted with bile, and enterohepatic circulation. About 10% to 15% of the injection volume is filtered from the glomerulus in its original form and excreted in the urine

Erythromycin, an organic compound with the chemical formula C37H67NO13, is a macrolide antibiotic, which is mainly used in the clinical application of streptococcal tonsillitis, scarlet fever, diphtheria and carriers, gonorrhea, listeriosis, streptococcus pneumoniae lower respiratory tract infection (the above applies to patients who are not resistant to penicillin for Legionella pneumonia and mycoplasma pneumonia, This product can be used as the drug of choice. It can also be used in upper respiratory tract infection caused by influenza bacillus, Staphylococcus aureus skin and soft tissue infection, syphilis, intestinal amoebiasis and so on.