Seripiprant 99% White powder cas 866460-33-5 senwayer

Androgenetic alopecia (AGA) is a common form of hair loss. In men, this condition is also known as male-pattern baldness. It develops at the top of the head or front of the scalp and worsens with age. Common treatments include finasteride and minoxidil. These treatments usually do not result in full hair regrowth. Setipiprant is an investigational oral medication for hair growth that works at specific possible molecular targets in the hair follicles. This was the first clinical study of the effect of setipiprant on hair growth in men with AGA. The study compared setipiprant with a placebo treatment and, for part of the study, finasteride, an AGA-targeted, 5-α-reductase inhibitor. Although the finasteride group was later removed to increase enrollment in the other study groups, a subset of subjects still completed the study. Men received treatment for 24 weeks and had follow-up visits through 32 weeks. Coprimary endpoints included change from baseline to week 24 in the target area hair count and in the subject’s self-assessment of change in hair growth. Setipiprant did not cause significant improvements in hair growth compared with placebo, but it was safe and well tolerated. Although differences between the finasteride group and the setipiprant and placebo groups were not evaluated statistically, the value of mean change in the coprimary endpoints was numerically greater in the finasteride group, as expected.