Duloxetine
HALAL KOSHER ISO FDA
116539-59-4
Pharmaceutical grade
0.99%
1KG;25KG;private logo
2023-09-01
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceDuloxetine (Cymbalta) is a newer antidepressant. It islargely like venlafaxine, which is an SNERI (selective norepinephrinereuptake inhibitor).
Solid
(S)-duloxetine is a duloxetine. It is an enantiomer of a (R)-duloxetine.|Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor. It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval for a variety of indications including the treatment of neuropathic pain, Generalized Anxiety disorder, osteoarthritis, and stress incontinence. Duloxetine continues to be investigated for the treatment of pain in cancer, surgery, and more.|Duloxetine is a Serotonin and Norepinephrine Reuptake Inhibitor. The mechanism of action of duloxetine is as a Norepinephrine Uptake Inhibitor, and Serotonin Uptake Inhibitor.|Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor widely used as an antidepressant and for neuropathic pain. Duloxetine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.|A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.CertificatesBasic Info-
Product Name:
Duloxetine
Other Name:2-Thiophenepropanamine,N-methyl-γ-(1-naphthalenyloxy)-,(γS)-;2-Thiophenepropanamine,N-methyl-γ-(1-naphthalenyloxy)-,(S)-;(γS)-N-Methyl-γ-(1-naphthalenyloxy)-2-thiophenepropanamine;LY 248686;Duloxetine;(S)-Duloxetine;(S)-(+)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine;(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine;(+)-Duloxetine;2-Thiophenepropanamine N-methyl-γ-(1-naphthalenyloxy)-,(γS)-;Ariclaim;Nodetrip;Xeristar
CAS No.:116539-59-4
Molecular Formula:C18H19NOS
InChIKeys:InChIKey=ZEUITGRIYCTCEM-KRWDZBQOSA-N
Molecular Weight:297.41
Exact Mass:297.41
EC Number:1533716-785-6
UNII:O5TNM5N07U
DSSTox ID:DTXSID6048385
ATC Code:N06AX21|N - Nervous system
HScode:2934999090
Categories:
Characteristics-
PSA:
49.5
XLogP3:4
Appearance:Solid
Density:1.158±0.06 g/cm3(Predicted)
Boiling Point:466.2±40.0 °C(Predicted)
Flash Point:9.7 deg C (49.5 deg F) - closed cup
Refractive Index:1.628
Water Solubility:2.96e-03 g/L
Storage Conditions:Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature -20 deg C
Vapor Pressure:1.18X10-7 mm Hg at 25 deg C (est)
Henrys Law Constant:Henry's Law constant = 4.53X10-10 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 9.70 (amine) (est)|White to slightly brownish white solid. pKa in dimethylformamide:water (66:34) = 9.6 Slightly soluble in water /Duloxetine hydrochloride/
Collision Cross Section:171 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]
Experimental Properties:Hydroxyl radical reaction rate constant = 3.1X10-10 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
