Dithranol 1143-38-0
1143-38-0
1kg/bag
2022-10-26
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceYellow Crystalline SolidChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.
Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.
Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.|Anthralin is an anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9. It has a role as an antipsoriatic. It derives from an anthrone. It is a tautomer of an anthracene-1,8,9-triol.|Anthralin (1,8‐dihydroxy‐9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized as a derivative of chrysarobin, obtained from the araroba tree in Brazil over 100 years ago. Adverse effects of anthralin include irritation and discoloration of the skin. This specific property of the molecule inspired workers to study details of its pharmacology. It is important to consider that the drug is relatively innocuous, yet effective, and systemic side effects have not been observed with this anthralin, in contrast to a wide variety of systemic and topical therapies for psoriasis. Anthralin is also known as dithranol. It is a main active ingredient in topical skin formulations for the treatment of psoriasis. Various formulations of the drug are available, including solutions, foams, and shampoos. The chemical structure of anthralin allows for dual solubility, permitting the compound to be absorbed well through the epidermis. Anthralin has also been studied in the treatment of warts, showing promising results. Salicylic acid is frequently added to anthralin to augment the stability of anthralin and to increase its penetration and efficacy.|Anthralin is a natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04)|An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.Basic Info-
Product Name:
Dithranol
Other Name:9(10H)-Anthracenone,1,8-dihydroxy-;Anthrone,1,8-dihydroxy-;1,8-Dihydroxy-9(10H)-anthracenone;1,8-Dihydroxyanthrone;1,8-Dihydroxy-9-anthrone;Anthra-Derm;Anthralin;Chrysodermol;Cigthranol;Dithranol;Psoriacid-Stift;Cignolin;Batridol;Lasan;Batidrol;DrithoCreme;Drithoscalp;Psodadrate;Psoriacide;NSC 43970;NSC 629313;Derobin;1,8-Dihydroxy-10H-anthracen-9-one;1,8-Dihydroxy-9,10-dihydroanthracen-9-one
CAS No.:1143-38-0
Molecular Formula:C14H10O3
InChIKeys:InChIKey=NUZWLKWWNNJHPT-UHFFFAOYSA-N
Molecular Weight:226.23
Exact Mass:226.23
BRN:2054360
EC Number:214-538-0
UNII:U8CJK0JH5M
NSC Number:755873|629313|43970
DSSTox ID:DTXSID7024538
NCI Thesaurus Code:C28827
ATC Code:D - Dermatologicals
HScode:29144000
Categories:
Characteristics-
PSA:
57.5
XLogP3:4.16
Appearance:Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.
Density:1.419±0.06 g/cm3(Predicted)
Melting Point:179 °C
Boiling Point:464.1±45.0 °C(Predicted)
Flash Point:248.6±25.2 °C
Refractive Index:1.710
Water Solubility:Insoluble in water. soluble in acetic acid, chloroform (20 mg/mL), acetone, benzene, solutions of alkali hydroxides, fixed oil. Slightly soluble in 95% ethanol, alcohol, ether, and glacial acetic acid.less than 1 mg/mL at 68° F (NTP, 1992)
Storage Conditions:2-8°C
Vapor Pressure:5.23E-09mmHg at 25°C
Collision Cross Section:142.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Air and Water Reactions:Unstable in air when in alkaline solution. Insoluble in water.
Reactive Group:Ketones
Reactivity Profile:ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture (NTP, 1992).
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
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Location:
hisense intelligence valley,no 2116,of phoenix road
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
7
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Total Annual Revenue:
Less than $1 million
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Total Employees:
11-50
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Year of Establishment:
2017
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
