Native Human Elastase
9004-06-2
96%
Yes
2026-11-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Native Human Elastase Cat No NATE-0213 Description Neutrophil elastase is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Abbr ELA2, Native (Human) Alias ELANE; ELA2 Source Human leuk ocytes Species Human Applications Elastase from Creative Enzymes has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leuk ocyte homogenateto examine the presence of fibronectin peptides in saliva of patients with Sjögren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on pr ocoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyel ocytic leukemia. Elastase from human leuk ocytes has been used in a study that determined that fragments of Nle3-angiotensin (1-7) accelerate healing in dermal models. Product Overview Leuk ocyte elastase is a 29 kDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds. It contains two or thee N-linked glycans of variable composition which account for its three major isoforms. Form Lyophilized from 0.05 M sodium acetate (pH 5.5) and 0.6 M NaCl Enzyme Commission Number EC 3.4.21.37 Activity > 50 units/mg protein (Bradford) CAS No 9004-06-2 Molecular Weight 29 kDa Isoelectric point 8.77-9.55 Unit Definition One unit will release one nanomole of p-nitrophenol per sec from Bec-L-alanine p-nitrophenyl ester at pH 6.5 at 37°C. Storage −20°C Pathway Activation of Matrix Metalloproteinases, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem Function bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protease binding; protein binding; serine-type endopeptidase activity Synonyms ELANE; elastase; EC 3.4.21.37; leukocyte elastase; ELA2; elastase 2; neutrophil elaszym; serine elastase; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elaszym; granulocyte elastase category Enzymes and Coenzymes Drugs(c1513) cas_num 9004-06-2 ECHEMI Editorial ReferenceElastase is white or light gray crystalline powder. It is soluble in water, stable at ph4-10.5 and 20C, and can be stored for 3-12 months at 60C. Compound elastase is a white ointment containing elastase and Neomycin sulfate.
Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes.Basic Info-
Product Name:
Elastase (human leucocytes)
Other Name:neutrophil elastase;PANCREATOPEPTIDASE E;LYSOSOMAL ELASTASE;macrophage metalloelastase;EC 3.4.21.36;EC 3.4.21.37;ELASTASE, LEUKOCYTE;ELASTASE, NEUTROPHIL, HUMAN
CAS No.:9004-06-2
Molecular Weight:0
EC Number:232-670-7
TSCA:TSCA listed
Color/Form:White to off-white
Categories:
Characteristics-
Appearance:
lyophilized powder
Storage Conditions:−20°C
Critical Temperature & Pressure:-20°C
Hazard IdentificationClassification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Respiratory sensitization, Category 1
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H315 Causes skin irritation
H319 Causes serious eye irritation
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 [In case of inadequate ventilation] wear respiratory protection.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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