PIK-75
372196-77-5
99%
2026-08-13
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName PIK-75 Cat No CEI-0135 Description PIK-75 can inhibit p110 alpha and DNA-PK with IC50 of 5.8 nM and 2 nM. CAS No 372196-77-5 Molecular Weight 488.74 Purity >99% Storage 2 years at -20centigrade Powder Targets p110 alpha, DNA-PK Molecular Formula C16H14BrN5O4S.HCl Chemical Name (E)-N-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride Solubility DMSO 3 mg/mL Water In vitro PIK-75 is a selective inhibitors of p110 alpha. PIK-75 can block the phosphorylation of PKB (akt) induced by insulin on both Ser 473 and Thr 308 in CHO-IR cells in a dose-dependent manner with an IC 50 of 78 nM. In 3T3-L1 pre-adipocytes, inhibition of p110-alpha by PIK-75 decreases the insulin-induced phosphorylation of PKB on both sites (Ser 473 and Thr 308 ). category Inhibitors(c1514) cas_num 372196-77-5 Basic Info-
Product Name:
PIK-75 Hydrochloride
Other Name:2-Methyl-5-nitrobenzenesulfonic acid [(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]methylhydrazide hydrochloride;PFK-15;(E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide hydrochloride;2-Methyl-5-nitrobenzenesulfonic acid [(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]methylhydrazide hydrochloridePIK-75;Benzenesulfonic acid, 2-methyl-5-nitro-, 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide, hydrochloride (1:1);(E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydraz;PIK-75 HCl
CAS No.:372196-77-5
Molecular Formula:C16H15BrClN5O4S
InChIKeys:VOUDEIAYNKZQKM-MYHMWQFYSA-N
Molecular Weight:488.7434
Exact Mass:486.972
Categories:
Characteristics-
PSA:
121
Density:1.7±0.1 g/cm3
Refractive Index:1.701
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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