SB590885
405554-55-4
99%
Yes
2026-11-24
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Description
ProductName SB590885 Cat No CEI-0149 Description SB590885(GSK2118436) can inhibit B-raf, B-Raf(V600E), and c-Raf with IC50 of 3.2 nM, 0.8 nM, and 5.0 nM. Alias GSK2118436 CAS No 405554-55-4 Molecular Weight 453.54 Purity >99% Storage 2 years at -20 centigrade Synonyms GSK2118436 Targets B-raf, B-Raf(V600E), c-Raf Molecular Formula C27H27N5O2 Chemical Name (E)-5-(2-(4-(2-(dimethylamino)ethoxy)phenyl)-4-(pyridin-4-yl)-1H-imidazol-5-yl)-2,3-dihydroinden-1-one oxime Solubility DSMO 5 mg/mL Water In vitro GSK2118436 is a novel, potent, and selective Raf kinase inhibitor that is capable of inhibiting the kinase activity of wild-type B-Raf, B-RafV600E and c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively. Kinase panel screening for over 270 kinases has indicated thatthis inhibitor is selective for Raf kinase, with 400 fold selectivitytowards B-Raf over 91% of the other kinases tested. Specificcellular inhibition of B-RafV600E kinase by this inhibitor leadsto decreased ERK phosphorylation and inhibition of cell proliferationby an initial arrest in the G1 phase of the cell cycle, followedby cell death. This inhibition is selective for cancer cellsthat specifically encode the mutation for B-Raf V600E. In vivo Oral compoundadministration inhibits the growth of B-RafV600E mutant melanoma(A375P) and colon cancer (Colo205) human tumor xenografts, growingsubcutaneously in immuno-compromised mice. category Inhibitors(c1514) cas_num 405554-55-4 ECHEMI Editorial ReferenceSB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases.
(Z)-SB-590885 is an N-{5-[2-{4-[2-(dimethylamino)ethoxy]phenyl}-4-(pyridin-4-yl)-1H-imidazol-5-yl]-2,3-dihydro-1H-inden-1-ylidene}hydroxylamine in which the oxime group has Z configuration.Basic Info-
Product Name:
SB 590885
Other Name:1H-Inden-1-one,5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-,oxime;5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime;SB 590885;SB 590885AAE
CAS No.:405554-55-4
Molecular Formula:C27H27N5O2
InChIKeys:InChIKey=MLSAQOINCGAULQ-UHFFFAOYSA-N
Molecular Weight:453.54
Exact Mass:453.54
Categories:
Characteristics-
PSA:
86.63000
XLogP3:4.87060
Appearance:white to beige
Density:1.3±0.1 g/cm3
Flash Point:371.8±31.5 °C
Refractive Index:1.666
Water Solubility:DMSO: soluble2mg/mL (clear solution, warmed)
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
