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SB 590885

SB 590885 structure

CAS No:
405554-55-4
Formula:
C27H27N5O2
Chemical Name:
SB 590885
Synonyms:
1H-Inden-1-one,5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-,oxime;5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime;SB 590885;SB 590885AAE
Categories:
Biochemical Engineering > Inhibitors

Description

SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, and has 11-fold greater selectivity for B-Raf over c-Raf, without inhibition to other human kinases.

(Z)-SB-590885 is an N-{5-[2-{4-[2-(dimethylamino)ethoxy]phenyl}-4-(pyridin-4-yl)-1H-imidazol-5-yl]-2,3-dihydro-1H-inden-1-ylidene}hydroxylamine in which the oxime group has Z configuration.

SB 590885 Basic Attributes

Molecular Weight：

453.54

Exact Mass：

453.54

Characteristics

PSA：

86.63000

XLogP3：

4.87060

Appearance：

white to beige

Density：

1.3±0.1 g/cm3

Flash Point：

371.8±31.5 °C

Refractive Index：

1.666

Water Solubility：

DMSO: soluble2mg/mL (clear solution, warmed)

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

SB-590885

Computed Properties

Molecular Weight:453.5
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:453.21647512
Monoisotopic Mass:453.21647512
Topological Polar Surface Area:86.6
Heavy Atom Count:34
Complexity:674
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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SB590885

CAS No.: 405554-55-4

Content: 99%

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