GDC-0879
905281-76-7
99%
2026-07-01
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName GDC-0879 Cat No CEI-0156 Description GDC-0879 can inhibit raf with IC50 of 63 nM CAS No 905281-76-7 Molecular Weight 334.37 Purity >99% Storage 2 years at -20 centigrade Targets raf Molecular Formula C19H18N4O2 Chemical Name (E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime Solubility DSMO 67 mg/mL Water In vitro As an ATP-competitive RAF kinase inhibitor, GDC-0879 show significant, equipotent inhibition of wild-type BRAF, BRAF(V600E), and CRAF. GDC-0879 inhibit BRAF-mutant Malme3M cells with EC 50 of 0.75 uM. Tumor cells with oncogenic mutations in either KRAS or NRAS showed limited dependence on BRAF activity and were frequently resistant to GDC-0879 treatment in vitro (EC 50 > 7.5 A mol/L for 28 of 32 cell lines). Cells with GDC-0879 EC 50 values In vivo Following tumor establishment (200-250 mm), animals were dosed once daily with 100 mg/kg GDC-0879 by oral gavage and tumor growth was monitored by caliper measurement. Daily treatment for 21 consecutive days induced significant tumor responses in LOX-IMVI, A375, and Colo205 xenografts (93%, 85%, and 53% tumor inhibition, respectively). Rapid tumor regression was observed for the majority of LOX-IMVI tumor-bearing mice and complete responses (regression of the established tumor beyond the level of detection by palpation) or partial responses (shrinkage of at least 50% relative to starting tumor volume) were observed in 10% and 70% of the animals. category Heterocyclic Compound(c1111) cas_num 905281-76-7 Basic Info-
Product Name:
GDC-0879
Other Name:GDC-0879;(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime,GDC-0879;2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime;1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxiMe;GDC 0849;(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime;2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-pyridin-4-yl-1H-pyrazol-1-yl}ethanol;(Z)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
CAS No.:905281-76-7
Molecular Formula:C19H18N4O2
InChIKeys:DEZZLWQELQORIU-RELWKKBWSA-N
Molecular Weight:334.377
Exact Mass:334.142975
UNII:E488J6BA6E
DSSTox ID:DTXSID00471110
Categories:
Characteristics-
PSA:
83.53000
XLogP3:1.12
Density:1.4±0.1 g/cm3
Boiling Point:562.6±50.0 °C at 760 mmHg
Flash Point:294.0±30.1 °C
Refractive Index:1.705
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product