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GDC-0879

GDC-0879 structure

CAS No:
905281-76-7
Formula:
C19H18N4O2
Chemical Name:
GDC-0879
Synonyms:
GDC-0879;(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime,GDC-0879;2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime;1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxiMe;GDC 0849;(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime;2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-pyridin-4-yl-1H-pyrazol-1-yl}ethanol;(Z)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

GDC-0879 is a potent and selective B-Raf inhibitor with an IC50 of 0.13 nM.

GDC-0879 is a member of the class of pyrazoles that is 1-(2-hydroxyethyl)pyrazole carrying additional 4-pyridyl and 1-(hydroxyimino)indan-5-yl substituents at positions 3 and 4 respectively. It has a role as a B-Raf inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of pyridines, a member of indanes, a ketoxime and a primary alcohol.

GDC-0879 Basic Attributes

Molecular Weight：

334.377

Exact Mass：

334.142975

UNII：

E488J6BA6E

DSSTox ID：

DTXSID00471110

Characteristics

PSA：

83.53000

XLogP3：

1.12

Density：

1.4±0.1 g/cm3

Boiling Point：

562.6±50.0 °C at 760 mmHg

Flash Point：

294.0±30.1 °C

Refractive Index：

1.705

Drug Information

MeSH Entry Terms：

2-(4-(1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl)-3-(pyridin-4-yl)-1H-pyrazol-1-yl)ethan-1-ol

Computed Properties

Molecular Weight:334.4
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:334.14297583
Monoisotopic Mass:334.14297583
Topological Polar Surface Area:83.5
Heavy Atom Count:25
Complexity:480
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime

CAS No.: 905281-76-7

Content: 99.00%

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GDC-0879

CAS No.: 905281-76-7

Content: 99%

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