GSK1120212(Trametinib)
1 Inquiries
871700-17-3
99%
2026-06-27
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName GSK1120212(Trametinib) Cat No CEI-0161 Description GSK1120212 can inhibit MEK1 and MEK2 with IC50 of 0.92 nM and 1.8 nM. Alias JTP-74057 CAS No 871700-17-3 Molecular Weight 615.3947932 Purity >99% Storage 2 years at -20centigrade Powder Synonyms JTP-74057 Targets MEK1, MEK2 Molecular Formula C26H23FIN5O4 Chemical Name N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide Solubility DMSO 5 mg/mL Water In vitro GSK1120212 inhibits MEK1/2 kinase activity and prevents Raf-dependent MEK phosphorylation (S217 for MEK1), producing prolonged p-ERK1/2 inhibition. GSK1120212 also reduced tumor Ki67, increased p27(Kip1/CDKN1B), and caused tumor growth inhibition in multiple tumor models. Treatment by GSK1120212 would result in growth inhibition accompanied with upregulation of p15INK4b and/or p27KIP1 in most of the colorectal cancer cell lines. In vivo The capability of GSK1120212 to inhibit ERK1/2 phosphorylation (p-ERK) in vivo was assessed in A-375P(F11) (melanoma encoding BRAFV600E mutation) xenograft model. GSK1120212(3 mg/kg), the 14-day MTD in nude mice, was administrated daily by oral gavage. category Inhibitors(c1514) cas_num 871700-17-3 Basic Info-
Product Name:
Trametinib
Other Name:Acetamide,N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-;N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide;JTP 74057;GSK 1120212;Trametinib;N-[3-[3-Cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;G 02442104;Mekinist;GSK 212;1204531-14-5
CAS No.:871700-17-3
Molecular Formula:C26H23FIN5O4
InChIKeys:InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Molecular Weight:615.3947932
Exact Mass:615.39
HScode:29339900
Categories:
Characteristics-
PSA:
102
XLogP3:3.4
Density:1.7±0.1 g/cm3
Melting Point:300-301 °C
Refractive Index:1.734
Hazard IdentificationClassification of the substance or mixture
Skin sensitization, Category 1
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H317 May cause an allergic skin reaction
H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
United States
Trametinib
5 KG May 29, 2025 Post an enquiry for this product