Pomalidomide
2 Inquiries
19171-19-8
99%
2026-07-18
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Pomalidomide Cat No CEI-0173 Description Pomalidomide can inhibit TNF-alpha release with IC50 of 13 nM. Alias CC-4047 CAS No 19171-19-8 Molecular Weight 273.24 Purity >99% Storage 2 years at -20centigrade Powder Synonyms CC-4047 Targets TNF-alpha Molecular Formula C13H11N3O4 Chemical Name 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Solubility DMSO 55 mg/mL Water In vitro Pomalidomide can inhibit TNF-alpha release with IC50 of 13 nM. Pomalidomide (CC-4047) exhibit anti-angiogenic, anti-proliferative, and pro-erythropoietic activities. Pomalidomide (CC-4047) shows anti-inflammatory effects on LPS-stimulated monocytes and decrease TNF-alpha. Pomalidomide (CC-4047) also shows costimulatory effects on anti-CD3 stimulated T cells and enhance T cell proliferation and proinflammatory cytokine production. Pomalidomide (CC-4047) can cause augmentation of NK-cell cytotoxic activity against tumour-cell targets. Pomalidomide cause cell cycle arrest in Burkitts lymphoma and multiple myeloma cell lines by increasing the level of p21(WAF-1) expression. Pomalidomide modify the chromatin structure of the p21(WAF-1) promoter through demethylation and acetylation of H3K9. In this way, pomalidomide plays an important role in the regulation of gene transcription. Pomalidomide used alone or in combination with hydroxyurea, may improve erythropoiesis and increase the ratio of fetal to adult hemoglobin. In vivo In Tsk-1 mice and in bleomycin-induced dermal fibrosis, treatment with pomalidomide in doses from 0.3 to 30 mg/kd/day prevented skin fibrosis in a dose-dependent manner and reduced the expression of transforming growth factor (TGF) beta-target genes such as PAI-1, CTGF and col 1a1. category Inhibitors(c1514) cas_num 19171-19-8 Basic Info-
Product Name:
Pomalidomide
Other Name:1H-Isoindole-1,3(2H)-dione,4-amino-2-(2,6-dioxo-3-piperidinyl)-;Phthalimide,3-amino-N-(2,6-dioxo-3-piperidyl)-;4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;CC 4047;Actimid;4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione;Pomalidomide;4-Amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione;2-(2,6-Dioxopiperidin-3-yl)-4-amino-isoindole-1,3-dione;4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Pomalyst;Imnovid;443912-23-0;443919-33-3
CAS No.:19171-19-8
Molecular Formula:C13H11N3O4
InChIKeys:InChIKey=UVSMNLNDYGZFPF-UHFFFAOYSA-N
Molecular Weight:273.24
Exact Mass:273.24
EC Number:1592732-453-0
Color/Form:Solid yellow powder
ATC Code:L04AX06|L - Antineoplastic and immunomodulating agents
HScode:29251900
Categories:
Characteristics-
PSA:
110
XLogP3:0.2
Appearance:yellow
Density:1.570±0.06 g/cm3(Predicted)
Melting Point:318.5 - 320.5°
Boiling Point:582.9±45.0 °C(Predicted)
Flash Point:306.3±28.7 °C
Refractive Index:1.691
Water Solubility:DMSO: ≥14mg/mL
Storage Conditions:2-8°C
Vapor Pressure:7.54X10-16 mm Hg at 25 deg C (est)
Dissociation Constants:pKa1 = 1.56 (aromatic amine); pKa2 = 11.59 (secondary amide) (est)
Experimental Properties:Henry's Law contant = 4.56X10-20 atm-cu m/mol at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Pomalidomide
1 KG May 27, 2025
Pakistan
Pomalidomide
1 KG May 26, 2025 Post an enquiry for this product