AT9283
896466-04-9
99%
2026-06-26
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AT9283 Cat No CEI-0195 Description AT9283 can inhibit Aurora A Kinase, Aurora B Kinase, JAK3, JAK2, and Abl with IC50 of 3 nM, 3 nM, 1.1 nM, 1.2 nM and 4 nM. CAS No 896466-04-9 Molecular Weight 381.43 Purity >99% Storage 2 years at -20centigrade Powder Targets Aurora A, Aurora B, JAK3, JAK2, Abl Molecular Formula C19H23N7O2 Chemical Name 1-cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea Solubility DMSO 76 mg/mL Water In vitro AT9283 can potently inhibit aurora kinase A and aurora kinase B with around 3 nM, both of which play a key role in regulating mitotic division and are attractive oncology targets. For cell lines (1)AT9283 potently inhibited proliferation and Jak2-related signalling in Jak2-dependent cell lines as well as inhibiting the formation of erythroid colonies from haematopoietic progenitors isolated from MPD patients with Jak2 mutations. (2)Besides inhibition to JAK, AT9283 also act as an aurora inhibitor. And exposure to AT9283 for one complete cell cycle committed an entire population of p53 checkpoint-compromised cells (HCT116) to multinucleation and death whereas treatment of p53 checkpoint-competent cells (HMEC, A549) for a similar length of time led to a reversible arrest of cells with 4N DNA. (3) AT9283 showed potent antiproliferative activity on cells transformed by wild-type BCR-ABL and BCR-ABL/T315I. AT9283 inhibited proliferation in a panel of BaF3 and human BCR-ABL(+) cell lines both sensitive and resistant to imatinib because of a variety of mechanisms. category Inhibitors(c1514) cas_num 896466-04-9 Basic Info-
Product Name:
AT9283
Other Name:1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283;AT9283, >=98%;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
CAS No.:896466-04-9
Molecular Formula:C19H23N7O2
InChIKeys:LOLPPWBBNUVNQZ-UHFFFAOYSA-N
Molecular Weight:381.438
Exact Mass:381.191315
UNII:XAV9KYN9WL
DSSTox ID:DTXSID20635838
HScode:2934999090
Categories:
Characteristics-
PSA:
110.96000
XLogP3:2.47090
Density:1.5±0.1 g/cm3
Refractive Index:1.715
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product