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AT9283

AT9283 structure

CAS No:
896466-04-9
Formula:
C19H23N7O2
Chemical Name:
AT9283
Synonyms:
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea AT9283;AT9283, >=98%;N-cyclopropyl-N'-[3-[5-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]Urea;Urea, N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-;1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
Categories:
Biochemical Engineering > Inhibitors

Description

AT9283 is a multitargeted kinase inhibitor which potently inhibits aurora kinase A/B, JAK2/3 (IC50=1.2 nM, 1.1 nM).

1-cyclopropyl-3-[3-[5-(4-morpholinylmethyl)-2-benzimidazolylidene]-1,2-dihydropyrazol-4-yl]urea is a member of benzimidazoles.

AT9283 Basic Attributes

Molecular Weight：

381.438

Exact Mass：

381.191315

UNII：

XAV9KYN9WL

DSSTox ID：

DTXSID20635838

HScode：

2934999090

Characteristics

PSA：

110.96000

XLogP3：

2.47090

Density：

1.5±0.1 g/cm3

Refractive Index：

1.715

Drug Information

MeSH Entry Terms：

1-cyclopropyl-3-(3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)urea

AT9283 Use and Manufacturing

Uses

AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = <1 μM) inhibits many other kinases, including serine/threonine kinases as well as receptor and non-receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential in cancer therapy. Consistent with this, AT-9283 is effective in preventing proliferation of cancer cells both in vitro and in vivo and this effect may be enhanced by combination therapy with other chemotherapeutics.[Cayman Chemical]

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:381.4
XLogP3:0.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:381.19132300
Monoisotopic Mass:381.19132300
Topological Polar Surface Area:111
Heavy Atom Count:28
Complexity:554
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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