OSI-420
183320-51-6
99%
2026-08-04
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName OSI-420 Cat No CEI-0013 Description As the major metabolite of Erlotinib, OSI-420 can inhibit EGFR with IC50 of 2 nM. CAS No 183320-51-6 Molecular Weight 415.87 Purity >99% Storage 2 years at -20 centigrade Targets EGFR Molecular Formula C21H21N3O4.HCl Chemical Name 2-(4-(3-ethynylphenylamino)-7-(2-methoxyethoxy)quinazolin-6-yloxy)ethanol hydrochloride Solubility DSMO 83 mg/mL Water 2 mg/ml Ethanol In vitro OSI-420 is the major metabolite of Erlotinib in human plasma. Erlotinib growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 uM. In vivo At doses of 100 mg/kg, Erlotinib completely prevents EGF-induced autophosphorylation of EGFR in human HN5 tumors growing as xenografts in athymic mice and of the hepatic EGFR of the treated mice. category Inhibitors(c1514) cas_num 183320-51-6 Basic Info-
Product Name:
OSI-420
Other Name:2-[[4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]ethanol hydrochloride;Ethanol, 2-[[4-[(3-ethynylphenyl)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride;OSI-420 (DesMethyl Erlotinib,CP-473420);CP-473420;DesMethyl Erlotinib;OSI-420 hydrochloride;OSI-420 (DesMethyl Erlotinib);Erlotinib O-DesMethyl Metabolite IsoMer (M14) HCl
CAS No.:183320-51-6
Molecular Formula:C21H21N3O4.HCl
InChIKeys:BUOXOWNQZVIETJ-UHFFFAOYSA-N
Molecular Weight:415.874
Exact Mass:415.129883
DSSTox ID:DTXSID50596524
Categories:
Characteristics-
PSA:
85.7
XLogP3:3.62600
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product