WZ4002
1213269-23-8
99%
Yes
2026-11-27
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Description
ProductName WZ4002 Cat No CEI-0014 Description As a novel, mutant-selective EGFR inhibitor, WZ4002 is can inhibit EGFR(L858R) and EGFR(L858R/T790M) with IC50 of 2 nM and 8 nM. CAS No 1213269-23-8 Molecular Weight 494.18 Purity >99% Storage 2 years at -20 centigrade Targets EGFR(L858R), EGFR(L858R/T790M) Molecular Formula C25H27ClN6O3 Chemical Name N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide Solubility DSMO 13 mg/mL Water In vitro As a novel, mutant-selective EGFR inhibitor, WZ4002 is can inhibit EGFR(L858R) and EGFR(L858R/T790M) with IC50 of 2 nM and 8 nM..WZ4002 can inhibit widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines.WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 and gefitinib. In vivo WZ4002 treatment results in significant tumor regressions compared to vehicle alone in both T790M containing murine models. category Inhibitors(c1514) cas_num 1213269-23-8 ECHEMI Editorial ReferenceWZ4002 is a mutant selective EGFR inhibitor with IC50s of 2, 8, 3 and 2 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750 and EGFRE746_A750/T790M, respectively.
WZ4002 is a pyrimidine compound having a 2-methoxy-4-(4-methylpiperazin-1-yl)anilino group at the 2-position, a 3-(acryloylamino)phenoxy group at the 4-position, and a chloro substituent at the 5-position. It has a role as a tyrosine kinase inhibitor and an antineoplastic agent. It is a member of pyrimidines, a member of piperazines and an organochlorine compound.Basic Info-
Product Name:
WZ4002
Other Name:WZ4002;N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS No.:1213269-23-8
Molecular Formula:C25H27ClN6O3
InChIKeys:ITTRLTNMFYIYPA-UHFFFAOYSA-N
Molecular Weight:494.99
Exact Mass:494.183319
EC Number:-0
UNII:6BQ432Z61M
DSSTox ID:DTXSID30153230
Categories:
Characteristics-
PSA:
91.8
XLogP3:4.2
Density:1.314
Refractive Index:1.648
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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