PD153035 HCL
183322-45-4
99%
2026-08-06
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName PD153035 HCL Cat No CEI-0016 Description PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM. CAS No 183322-45-4 Molecular Weight 396.67 Purity >99% Storage 2 years at -20 centigrade Targets EGFR Molecular Formula C16H14BrN3O2.HCl Chemical Name N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride Solubility DSMO 0.5 mg/mL Water In vitro PD153035 can inhibit epidermal growth factor (EGF) receptor tyrosine kinase with Ki of 6 pM. PD153035 can potently suppresses tyrosine phosphorylation of the EGF receptor in A431 cells at nanomolar concentrations. PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and clonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF was completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor. In vivo In A431 human epidermoid tumors grown as xenografts in immunodeficient nude mice, PD153035(80 mg/kg) suppresse the tyrosine phosphorylation of the EGF receptor rapidly by 80-90% in the tumors. category Inhibitors(c1514) cas_num 183322-45-4 Basic Info-
Product Name:
4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)
Other Name:4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-,hydrochloride (1:1);4-Quinazolinamine,N-(3-bromophenyl)-6,7-dimethoxy-,monohydrochloride;6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride
CAS No.:183322-45-4
Molecular Formula:C16H14BrN3O2.ClH
InChIKeys:InChIKey=ZJOKWAWPAPMNIM-UHFFFAOYSA-N
Molecular Weight:396.669
Exact Mass:395.003601
UNII:AHJ252P69N
DSSTox ID:DTXSID30171414
HScode:2933990090
Categories:
Characteristics-
PSA:
56.3
Appearance:white to beige
Melting Point:256-257.5 °C
Boiling Point:472.1°C at 760 mmHg
Flash Point:239.3ºC
Water Solubility:DMSO: soluble2mg/mL, clear (warmed)
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Skin irritation, Category 2
Serious eye damage, Category 1
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H315 Causes skin irritation
H318 Causes serious eye damage
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P317 Get medical help.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product