VX-222
1026785-55-6
99%
2026-07-25
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName VX-222 Cat No CEI-0225 Description VX-222 Alias VCH222 CAS No 1026785-55-6 Molecular Weight 445.61 Purity >99% Storage 2 years at -20 centigrade Synonyms VCH222 Targets HCV NS5B 1alpha, HCV NS5B 1beta Molecular Formula C25H35NO4S Solubility No In vitro As a nonnucleoside inhibitor, VX-222 (VCH-222) can potently and selectively inhibit HCV polymerase with IC50 of 0.94-1.2 uM. VX-222 binds to the HCV polymerase with dissociation constants of 17 nM. VX-222 can inhibit HCV replication via NS5B (polymerase of hepatitis C virus).VX-222 interfered with the interaction between NS5B and RNA. VX-222 inhibited the 1b/Con1 HCV subgenomic replicon, with EC50 of 5 nM. The inhibitory activity of VX-222 was only modestly affected by the M423T substitution but more significantly affected by an I482L substitution. category Specialty Chemicals(c26) cas_num 1026785-55-6 Basic Info-
Product Name:
5-(3,3-diMethylbut-1-yn-1-yl)-3-(N-(4-hydroxycyclohexyl)-4-MethylcyclohexanecarboxaMido)thiophene-2-carboxylic acid
Other Name:5-(3,3-diMethylbut-1-yn-1-yl)-3-(N-(4-hydroxycyclohexyl)-4-MethylcyclohexanecarboxaMido)thiophene-2-carboxylic acid;5-(3,3-Dimethyl-1-butynyl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]thiophene-2-carboxylic acid;Lomibuvir;VX-222 (S1480;5-(3,3-DIMETHYLBUT-1-YN-1-YL)-3-((1R,4R)-N-((1R,4R)-4-HYDROXYCYCLOHEXYL)-4-METHYLCYCLOHEXANE-1-CARBOXAMIDO)THIOPHENE-2-CARBOXYLIC ACID
CAS No.:1026785-55-6
Molecular Formula:C25H35NO3S
InChIKeys:WPMJNLCLKAKMLA-UHFFFAOYSA-N
Molecular Weight:429.6153
Exact Mass:445.229
UNII:37L2LF4A2D
Categories:
Characteristics-
PSA:
106
XLogP3:5.9
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product