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Nepicastat hydrochloride

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CAS No.:

170151-24-3

Content:

99%

Price valid (until):

2026-08-12

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Inquiry History

Description

ProductName	Nepicastat hydrochloride
Cat No	CEI-0242
Description	As a novel inhibitor, nepicastat hydrochloride can potently inhibit bovine and human dopamine-beta-hydroxylase with IC50 of 8.5 nM and 9 nM. respectively.
Alias	SYN117
CAS No	170151-24-3
Molecular Weight	331.81
Purity	>99%
Storage	2 years at -20 centigrade
Synonyms	SYN117
Targets	bovine dopamine-beta-hydroxylase, human dopamine-beta-hydroxylase
Molecular Formula	C14H15F2N3S.HCl
Chemical Name	(S)-5-(aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione hydrochloride
Solubility	DSMO 66 mg/mL Water
In vitro	Nepicastat hydrochloride shows the selective and concentration-dependent inhibition effects on bovine and human dopamine-beta-hydroxylase activity with IC50 of 8.5 nM and 9.0 nM.
In vivo	In inactin-anesthetized SHRs, Nepicastat hydrochloride (3 mg/kg, i.v.) produces the antihypertensive effects and causes a significant decrease in renal vascular resistance (38%) and an increase in renal blood flow (22%).
category	Inhibitors(c1514)
cas_num	170151-24-3

Basic Info

Product Name:

Nepicastathydrochloride

Other Name:

Nepicastat HCl (SYN-117),Nepicastat hydrochloride,;Nepicastat (SYN-117) HCl;(S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride;Nepicastat (SYN117)HCI;RS 25560-197Nepicastat hydrochloride;5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride;5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride;Nepicastat HCl, >=99%

CAS No.:

170151-24-3

Molecular Formula:

C14H16ClF2N3S

InChIKeys:

DIPDUAJWNBEVOY-PPHPATTJSA-N

Molecular Weight:

331.812

Exact Mass:

331.072144

Categories:

Inhibitors

Characteristics

PSA:

73.4

XLogP3:

4.51490

Appearance:

white to beige

Water Solubility:

DMSO: soluble10mg/mL, clear

Storage Conditions:

-20°C

See More Nepicastathydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Nepicastathydrochloride Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Encenicline Hcl	10 G	Feb 28, 2024

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