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Nepicastathydrochloride

Nepicastathydrochloride structure

CAS No:
170151-24-3
Formula:
C14H16ClF2N3S
Chemical Name:
Nepicastathydrochloride
Synonyms:
Nepicastat HCl (SYN-117),Nepicastat hydrochloride,;Nepicastat (SYN-117) HCl;(S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride;Nepicastat (SYN117)HCI;RS 25560-197Nepicastat hydrochloride;5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride;5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride;Nepicastat HCl, >=99%
Categories:
Biochemical Engineering > Inhibitors

Description

Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase)Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.

Nepicastathydrochloride Basic Attributes

Molecular Weight：

331.812

Exact Mass：

331.072144

Characteristics

PSA：

73.4

XLogP3：

4.51490

Appearance：

white to beige

Water Solubility：

DMSO: soluble10mg/mL, clear

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

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Nepicastat hydrochloride

CAS No.: 170151-24-3

Content: 99%

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