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TAME

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CAS No.:

901-47-3

Content:

99%

Sample Available:

Yes

Price valid (until):

2026-11-02

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Payment Terms:

TT against copy of documents,D/P

Average Lead Time:

15 days

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Description

ProductName	TAME
Cat No	CEI-0278
Description	Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.
CAS No	901-47-3
Molecular Weight	342.41
Purity	>99%
Storage	2 years at -20 centigrade
Targets	APC
Molecular Formula	C14H22N4O4S
Chemical Name	(S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate
Solubility	DSMO 69 mg/mL Water 69 mg/mL Ethanol 3 mg/mL
In vitro	TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM. TAME at concentration of 1-200 uM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME accelerates the ATP hydrolysis process about 12-fold. TAME interacts with beta and gamma phosphate and the adenine ring of ATP by the guanidinium group and the aromatic ring.
category	Amino Acids and Derivatives(c1517)
cas_num	901-47-3

ECHEMI Editorial Reference

TAME is an inhibitor of anaphase-promoting complex (APC), which prevents its activation by Cdc20 and Cdh1; TAME is also an inhibitor of cyclin proteolysis in mitotic Xenopus egg extract, with an IC50 of 12 µM.
TAMe is an L-arginine ester that is methyl L-argininate in which one of the hydrogens attached to the alpha-nitrogen is substituted by a tosyl group. It is a L-arginine ester, a sulfonamide, a methyl ester and a member of guanidines.|Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).

Basic Info

Product Name:

α-Tosyl-L-arginine methyl ester

Other Name:

L-Arginine,N2-[(4-methylphenyl)sulfonyl]-,methyl ester;Arginine,N2-(p-tolylsulfonyl)-,methyl ester,L-;Arginine,(p-tolylsulfonyl)-,methyl ester;TAME (pharmaceutical);α-N-p-Toluenesulfonyl-L-arginine methyl ester;Methyl p-toluenesulfonyl-L-argininate;Methyl Nα-p-toluenesulfonyl-L-argininate;α-Tosyl-L-arginine methyl ester;p-Toluenesulfonyl-L-arginine methyl ester;p-Tolylsulfonyl-L-arginine methyl ester;N1-Tosyl-L-arginine methyl ester;p-Tosyl-L-arginine methyl ester;N-α-Toluenesulfonyl-L-arginine methyl ester;α-N-p-Tosyl-L-arginine methyl ester;TAME;(S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate;2706-74-3

CAS No.:

901-47-3

Molecular Formula:

C14H22N4O4S

InChIKeys:

InChIKey=FKMJXALNHKIDOD-LBPRGKRZSA-N

Molecular Weight:

342.414

Exact Mass:

342.41

UNII:

1H7BKF44U1

Categories:

Amino Acids and Derivatives

Characteristics

PSA:

142.75000

XLogP3:

0.77

Density:

1.3±0.1 g/cm3

Melting Point:

-80°C

Boiling Point:

516.5±60.0 °C at 760 mmHg

Flash Point:

266.1±32.9 °C

Refractive Index:

1.591

Vapor Density:

Relative vapour density (air = 1): 3.6

Explosive limit:

Explosive limits , vol% in air: 1.1-7.1

See More α-Tosyl-L-arginine methyl ester Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More α-Tosyl-L-arginine methyl ester Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15 days

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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China Most Professional Manufacturer Supply High Quality P-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCL CAS 901-47-3	Pharmaceutical Grade/99		LEADER BIOCHEMICAL GROUP	Inquiry

TAME

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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