OC000459
1 Inquiries
851723-84-7
0.99%
2026-08-12
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName OC000459 Cat No CEI-0333 Description OC000459 is an indole-acetic acid derivative that potently displaces PGD2 from human recombinant D prostanoid receptor 2 with Ki of 13 nM, rat recombinant D prostanoid receptor 2 with Ki of 3 nM, and human native D prostanoid receptor 2 with Ki of 4 nM. Alias OC-000459, OC 000459 CAS No 851723-84-7 Molecular Weight 348.4 Purity 0.99 Storage 2 years -20centigrade Powder Synonyms OC-000459, OC 000459 Targets human recombinant DP2 Molecular Formula C21H17FN2O2 Chemical Name 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid Solubility DMSO:PBS(1:1) 0.5 mg/mL In vitro VX-950 is a potent, small molecule, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3.4A serine protease. Although competitive with the peptide substrate in the active site, VX-950 exhibits apparent noncompetitive inhibition as a result of its tight binding properties and time-dependent inhibition mechanism. Incubation of the HCV Con1 subgenomic replicon cells with VX-950 results in a concentration-dependent decline of the HCV RNA level. The dominant resistance mutation observed against VX-950 was a substitution of Ala156 in the HCV NS3 protease domain with a serine. VX-950 demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells with IC50 of 354 nM and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera with IC50 of 280 nM. VX-950 forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant Ki of 7 nM. [1][2] category Inhibitors(c1514) cas_num 851723-84-7 Basic Info-
Product Name:
OC000459
Other Name:OC000459;2-(5-fluoro-2-Methyl-3-(quinolin-2-ylMethyl)-1H-indol-1-yl)acetic acid;5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459);[5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid;5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid;OC000495;(5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid;1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
CAS No.:851723-84-7
Molecular Formula:C21H17FN2O2
InChIKeys:FATGTHLOZSXOBC-UHFFFAOYSA-N
Molecular Weight:348.3702832
Exact Mass:348.127411
UNII:04XB9TB8OL
DSSTox ID:DTXSID00234343
HScode:2933990090
Categories:
Characteristics-
PSA:
55.1
XLogP3:4.37
Density:1.3±0.1 g/cm3
Boiling Point:574.4±50.0 °C at 760 mmHg
Flash Point:301.2±30.1 °C
Refractive Index:1.646
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Oc000459
3000 MG Nov 21, 2025 Post an enquiry for this product