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OC000459

OC000459 structure

CAS No:
851723-84-7
Formula:
C21H17FN2O2
Chemical Name:
OC000459
Synonyms:
OC000459;2-(5-fluoro-2-Methyl-3-(quinolin-2-ylMethyl)-1H-indol-1-yl)acetic acid;5-Fluoro-2-Methyl-3-quinolin-2-ylMethylindo-1-yl)-acetic(OC000459);[5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid;5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indole-1-acetic acid;OC000495;(5-Fluoro-3-isoquinolin-3-ylMethyl-2-Methyl-indol-1-yl)-acetic acid;1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
Categories:
Biochemical Engineering > Inhibitors

Description

OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.IC50 Value: 13 nM( Ki for hrCRTH2); 3 nM( Ki for Rat rCRTH2);13 nM(Ki for human native CRTH2)Target: D prostanoid receptor 2CRTH2 (chemoattractant receptor expressed on T-helper (Th) type 2 cells) is a G-protein-coupled receptor expressed by Th2 lymphocytes and eosinophils that mediates prostaglandin (PG)D(2)-driven chemotaxis[1]. CRTH2 mediates activation of Th2 cells, eosinophils and basophil

OC000459 is under investigation for the treatment of Severe Eosinophilic Asthma. OC000459 has been investigated for the treatment of Bronchial Asthma.

OC000459 Basic Attributes

Molecular Weight：

348.3702832

Exact Mass：

348.127411

UNII：

04XB9TB8OL

DSSTox ID：

DTXSID00234343

HScode：

2933990090

Characteristics

PSA：

55.1

XLogP3：

4.37

Density：

1.3±0.1 g/cm3

Boiling Point：

574.4±50.0 °C at 760 mmHg

Flash Point：

301.2±30.1 °C

Refractive Index：

1.646

Drug Information

MeSH Entry Terms：

(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid

OC000459 Use and Manufacturing

OC000459 is a CRTH2 antagonist which helps in the treatment of allergies, reducing nasal and ocular symptoms in subjects exposed to allergens.

Computed Properties

Molecular Weight:348.4
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:348.12740595
Monoisotopic Mass:348.12740595
Topological Polar Surface Area:55.1
Heavy Atom Count:26
Complexity:516
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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