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Enalaprilat

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CAS No.:

84680-54-6

Content:

99%

Price valid (until):

2026-07-08

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Creative Enzymes

Company Type:

Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Description

ProductName	Enalaprilat
Cat No	CEI-0347
Description	Enalaprilat
CAS No	84680-54-6
Molecular Weight	348.4
Purity	>99%
Storage	2 years at -20centigrade Powder
Targets	ACE
Molecular Formula	C18H24N2O5.2H2O
Solubility	DMSO 70 mg/mL, Water 5 mg/mL, Ethanol 1 mg/mL
In vitro	Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykiningiotensin I selectivity ratio of 1.00 calculated from double displacement experiments. Enalaprilat has the strong inhibitory effect on Abeta42-to-Abeta40-converting activity found in the N-domain of ACE, exhibiting a 10-fold lower IC50 (0.003~0.01 uM) than captopril (0.03~0.1 uM). Enalaprilat (100 nM) blocks protein kinase C epsilon by directly activating bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in cytokine-treated human lung microvascular endothelial cells.
category	Inhibitors(c1514)
cas_num	84680-54-6

Basic Info

Product Name:

N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline hydrate (1:2)

Other Name:

L-Proline,N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-,hydrate (1:2);L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,dihydrate,(S)-;L-Proline,N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-,dihydrate;N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline hydrate (1:2)

CAS No.:

84680-54-6

Molecular Formula:

C18H24N2O5.2H2O

InChIKeys:

InChIKey=MZYVOFLIPYDBGD-MLZQUWKJSA-N

Molecular Weight:

384.42

Exact Mass:

384.189636

EC Number:

278-459-3

HScode:

2933995300

Categories:

Inhibitors

Characteristics

PSA:

109

XLogP3:

1.32630

Melting Point:

151-159°C

Boiling Point:

601°C at 760 mmHg

Flash Point:

294.6ºC

Refractive Index:

1.579

Water Solubility:

H2O: soluble 14mg/mL at 60°C (warming for 5 minutes)

Storage Conditions:

-20°C Freezer

See More N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline hydrate (1:2) Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H336 May cause drowsiness or dizziness H361 Suspected of damaging fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline hydrate (1:2) Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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