AIM-100
873305-35-2
0.98%
2026-08-03
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AIM-100 Cat No CEI-1201 Product Overview AIM-100 is a small inhibitor of Ack1 tyrosine kinase with IC50 value of 24 nM. AIM-100 mimicked ATP and inhibited the activity of Ack1 significantly and specifically. It showed no inhibition activity for the other 30 kinases including PI3-kinase and AKT, and showed a five-fold higher IC50 value for Lck. In MEF cells treated with EGF, AIM-100 caused a remarkable decrease of the activation of Ack1. In the human prostate cancer cells LNCaP and LAPC4, AIM-100 treatment resulted in an increase of G0/G1 cell phase and subsequent cell growth suppression. These effects of AIM-100 also exerted in the pancreatic cancer cells. AIM-100 induced apoptosis in Panc-1 cells at concentration of 10 μM. Moreover, AIM-100 inhibited cell growth with GI50 values of 7 to 8 μM in CD-18, Panc-1, OV90, MCF-7 and MDA-MB-468 cancer cells. CAS No 873305-35-2 Molecular Weight 371.43 Purity 0.98 Storage Store at -20°C Synonyms AIM 100; AIM100 Targets Ack1 Molecular Formula C23H21N3O2 Chemical Name N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 873305-35-2 Basic Info-
Product Name:
AIM-100
Other Name:5,6-diphenyl-N-((2S)-tetrahydro-2-furanylmethyl)furo(2,3-d)pyrimidin-4-amine;AIM-100;furo(2,3-d)pyrimidin-4-amine, 5,6-diphenyl-N-(((2S)-tetrahydro-2-furanyl)methyl)-;AIM 100;CHEMBL247070;N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine;(S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;5,6-Diphenyl-N-[[(2S)-tetrahydrofuran-2-yl]methyl]furo[2,3-d]pyrimidin-4-amine;MLS006010340
CAS No.:873305-35-2
Molecular Formula:C23H21N3O2
InChIKeys:XNFHHOXCDUAYSR-SFHVURJKSA-N
Molecular Weight:371.43174
Exact Mass:371.163
Categories:
Characteristics-
PSA:
60.2
XLogP3:5
Density:1.243±0.06 g/cm3(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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