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Daclatasvir dihydrochloride
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BMS-790052 dihydrochloride
BMS-790052 dihydrochloride
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CAS No.:
1009119-65-6
Content:
0.98%
Price valid (until):
2026-06-29
Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName BMS-790052 dihydrochloride Cat No CEI-1257 Product Overview BMS-790052 is a potent inhibitor of HCV NS5A with EC50 value of 9-50 pM. NS5A (nonstructural protein 5A) is a zinc-binding protein and plays a pivotal role in HCV RNA replication. NS5A involves in mediating the host cell function and HCV infection, therefore, it is regarded as a promising target for HCV treatment. BMS-790052 is a selective HCV NS5A inhibitor and has the most potent ability to inhibit HCV replication reported so far. When using FRET assays to determine the efficiay of BMS-790052 on HCV NS5A, replicon cells were cultured in 96-well plates and after 12 hours BMS-790052 was added to test the replication activity and cytotoxicity, the results showed that the mean values of BMS-790052 for genotype 1a and 1b were 50 and 9 pM, respectively. In stable replication cell lines with GT-5a hybrid replicons (GT-5a-6, GT-5a-7, and GT-5a-9), BMS-790052 treatment showed effective antiviral activity with EC50 values range from 3 to 7 pM. It has been shown that oral administration of BMS-790052 was safe and well tolerated up to 200 mg when tested with healthy people, and it was safe and well tolerated at the dose of 100 mg when tested with HCV-infected patients. CAS No 1009119-65-6 Molecular Weight 811.8 Purity 0.98 Storage Store at -20°C Synonyms Daclatasvir dihydrochloride; BMS790052 dihydrochloride; BMS 790052 dihydrochloride Targets HCV NS5A Molecular Formula C40H52Cl2N8O6 Chemical Name dimethyl ((2S,2S)-((2S,2S)-2,2-(5,5-([1,1-biphenyl]-4,4-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate dihydrochloride Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Bulk Drug Intermediates(c1112) cas_num 1009119-65-6 Basic Info-
Product Name:
Daclatasvir dihydrochloride
Other Name:Carbamic acid,N,N′-[[1,1′-biphenyl]-4,4′-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-,C,C′-dimethyl ester,hydrochloride (1:2);Daclatasvir dihydrochloride;BMS 790052-05;Daklinza
CAS No.:1009119-65-6
Molecular Formula:C40H50N8O6.2ClH
InChIKeys:InChIKey=BVZLLUDATICXCI-JMSCDMLISA-N
Molecular Weight:811.8
Exact Mass:810.3386868
UNII:50ZO25C11D
NCI Thesaurus Code:C166798
ATC Code:J05AP07
Categories:
Characteristics -
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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