High Quality Wholesale Price 1009119-65-6 Raw Material Bulk Daclatasvir HCL Powder
KOSHER ISO FDA
1009119-65-6
Food grade
99%
shen zhen
Flying
10g/1kg/ 10kg/ 25kg
2023-11-19
vitamin
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceDaclatasvir hydrochloride is a hydrochloride obtained by combining daclatasvir with two molar equivalents of hydrochloric acid. It is a potent inhibitor of nonstructural protein 5A and is used for treatment of hepatitis C. It has a role as an antiviral drug and a nonstructural protein 5A inhibitor. It contains a daclatasvir(2+).|Daclatasvir Dihydrochloride is the dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Although the exact mechanism of action of daclatasvir has yet to be fully determined, this agent, upon oral administration and after intracellular uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.
Daclatasvir dihydrochloride is a hepatitis C virus nonstructural 5A (NS5A) replication complex inhibitor which was first approved in Japan for the treatment of genotype 1 HCV patients who fail to respond to interferon plus ribavirin. The drug has also been approved for patients with untreated, chronic HCV who are eligible for interferon. Additionally, in Europe, daclatasvir was approved for use in combination with other products across genotype 1–4 HCV. Daclatasvir was discovered and developed by Bristol–Myers Squibb and a fascinating account describing the initiation of the program from a phenotypic screen and the medicinal chemistry strategy leading to the discovery of the compound has been recently reported.
Daclatasvir dihydrochloride is white to yellow powder. It is freely soluble in water (>700 mg/mL). The solubility is strongly pH-dependent and the solubility is high at low pH values.CertificatesBasic Info-
Product Name:
Daclatasvir Dihydrochloride
Other Name:BMS 790052;BMS-790052;BMS790052 ;BMS 790052;DACLATASVIR;BMS-790052 DIHYDROCHLORIDE;BMS790052 DIHYDROCHLORIDE;BMS 790052 DIHYDROCHLORIDE;BMS-790052; BMS790052 ; BMS 790052;DACLATASVIR;Daclatasvir dihydrochloride (BMS-790052);BMS 790052 (di HClsalt);N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-;Daclatasvir dihydrochloride (BMS-790052 dihydrochloride);Dacatavir dihydrochloride
CAS No.:1009119-65-6
Molecular Formula:C40H51ClN8O6
InChIKeys:AQVSGTIFAZLGND-DDOLUWEFNA-N
Molecular Weight:775.35
Exact Mass:810.3386868
EC Number:816-965-3
UNII:50ZO25C11D
NCI Thesaurus Code:C166798
Color/Form:Off-White to Yellow
ATC Code:J05AP07
Categories:
Characteristics-
Melting Point:
>207°C (dec.)
Critical Temperature & Pressure:-20°C Freezer
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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